Biopsychosocial pain predictors of mobility decline in aging

项目概要/摘要。行动不便影响大约30%的60-69岁的人，40%的 年龄在70-79岁之间的人，以及80岁或以上的人的55%。新出现的横截面证据表明， 自我报告的肌肉骨骼疼痛可能是与年龄相关的活动能力下降的主要驱动因素之一。尽管如此 证据表明，由于慢性肌肉骨骼疼痛之间的关系， 老年人的年龄、活动能力、心理社会功能和大脑还没有在同一个老年人中进行纵向研究。 个体我们的前瞻性研究设计将为疼痛相关的大脑变化的作用提供新的信息 作为与年龄相关的流动性下降的预测因素。这项拟议中的工作将使我们能够确定疼痛是否 以及大脑结构和功能预测纵向移动性下降（目标1），以及大脑是否测量 前瞻性地介导疼痛-活动性关联（目的2）。研究结果可能支持将疼痛的 对大脑的影响转化为针对衰老中活动能力下降的治疗方法。这项工作将多个 研究领域内的生物心理社会的方法来研究疼痛和流动性的老年人口。

Project Summary/Abstract. Mobility disability impacts approximately 30% of individuals aged 60-69, 40% of individuals aged 70-79, and 55% of individuals age 80 or older. Emerging cross-sectional evidence suggests that self-reported musculoskeletal pain may be one of the major drivers of age-related mobility decline. Despite this evidence, significant knowledge gaps remain because the relationships among chronic musculoskeletal pain, aging, mobility, psychosocial function, and the brain have not been studied longitudinally in the same older individuals. Our prospective study design will provide novel information on the role of pain-related brain changes as predictive factors of age-related mobility decline. The proposed work will allow us to determine whether pain as well as brain structure and function predict mobility decline longitudinally (Aim 1) and whether brain measures mediate the pain-mobility association prospectively (Aim 2). Findings may support the value of incorporating pain’s impact on the brain into treatments that target mobility decline in aging. The proposed work integrates multiple fields of study within a biopsychosocial approach to study pain and mobility in the older population.