Enhancing Precision of Estimates of Sexual Orientation and Gender Identity Disparities in Tobacco and Cannabis use in Young People

行政补充项目项目总结 本申请是对特别利益通知(NOSI)的回应，该通知被标识为“非CA-CA- 23-032.获得与性行为有关的烟草产品和大麻使用差异的估计 青少年和青年(AYA)的定向和性别认同(SOGI)对于了解 扭转癌症不平等的战略。现有的对SOGI差异的估计使用的衡量标准是 包容性不够，不清楚差距是否延伸到经常被忽视的特定SOGI (例如，无性、泛性、性别非二元性)。为了解决这一差距，本行政副刊将进行 8种不同性取向身份与5种不同性别关联性的新二次分析 对8种不同烟草和大麻产品的使用和多种用途的认同。我们利用NCI资助的 R01家长项目(R01-CA0229617)，包括对3915名青少年和2526名青少年进行的纵向队列研究 研究尼古丁和大麻蒸发的风险因素和后果的成年人。每年5次(每半年) 2019年至2023年进行的调查，正在收集烟草和大麻产品使用的详细数据 母公司R01‘S的主要目标和详细的SOGI数据正在收集中，以获得有关 一群人。本补编要求提供资金，以支付调查人员和统计学家进行 为这一新的二次分析进行数据分析和手稿准备。本增刊的主要目的是 项目是确定不同的SOGI与过去30天的烟草和大麻的同时关联 青少年队列和青年队列中的产品使用频率和多用途状态。第二个 目标是检查这些关联是否在变化的与静态的SOGI的个体之间存在差异， 按时间顺序，以及种族/民族。因为我们反复测量SOGI和烟草/大麻 使用时，我们将分别拥有多达14,843和9103个青少年和青年队列的数据点，这些数据点 将提供前所未有的力量来检查较低患病率的SOGI(例如，无性恋者、泛性恋者、质疑 性行为、性别非二元)。在这个行政副刊项目结束时，我们将有一些 对烟草和大麻产品使用中SOGI差异的最新、最全面和最详细的估计 在脆弱的阿亚斯人中。这将告知：(A)为减少SOGI癌症而采取的精确公共卫生措施 差距；以及(B)在国家烟草/大麻使用调查中是否需要更全面地衡量SOGI 为了避免忽视差距，从而避免忽视需要干预的群体。

PROJECT SUMMARY FOR ADMINISTRATIVE SUPPLEMENT PROJECT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 23-032. Obtaining estimates of disparities in tobacco product and cannabis use associated with sexual orientation and gender identity (SOGI) among adolescents and young adults (AYAs) is vital for informing strategies to reverse cancer inequities. Existing estimates of SOGI disparities use measures that are insufficiently inclusive, leaving unclear whether disparities extend to specific SOGIs that are often overlooked (e.g., asexual, pansexual, gender non-binary). To address this gap, this administrative supplement will conduct a new secondary analysis of the association of 8 different sexual orientation identities and 5 different gender identities with the use and poly-use of 8 different tobacco and cannabis products. We leverage a NCI-funded R01 parent project (R01-CA0229617) including longitudinal cohort studies of 3,915 adolescents and 2,526 young adults that examines risk factors and consequences of nicotine and cannabis vaping. At each of 5 (semi)annual survey waves conducted 2019-2023, detailed data on tobacco and cannabis product use are being collected for the parent R01’s primary aims, and detailed SOGI data are being collected for descriptive information about the cohorts. This supplement requests funding to cover salary effort for investigators and statisticians to conduct data analysis and manuscript preparation for this new secondary analysis. The primary goal of the supplement project is to determine the concurrent association of various SOGIs with past-30-day tobacco and cannabis product use frequency and poly-use statuses in an adolescent cohort and in a young adult cohort. The secondary goals are to examine whether these associations vary across individuals with changing vs. static SOGIs, chronological time, and race/ethnicity. Because we have repeated measures of SOGI and tobacco/cannabis use, we will have up to 14,843 and 9103 data points for adolescent and young adult cohorts, respectively, which will provide unprecedented power to examine lower prevalence SOGIs (e.g., asexual, pansexual, questioning sexuality, gender non-binary). At the end of this Administrative Supplement project, we will have some of the most contemporary, inclusive, and detailed estimates of SOGI disparities in tobacco and cannabis product use in the vulnerable population of AYAs. This will inform: (a) precise public health measures to reduce SOGI cancer disparities; and (b) if more inclusive measurement of SOGI is needed in national tobacco/cannabis use surveys of AYAs in order to avoid overlooking disparities and, in turn, groups in need of intervention.