Pittsburgh Liver Research Center

摘要（来自母基金P30 DK 120531，标题为匹兹堡肝脏研究中心; PI：Monga，Satdarshan）： 匹兹堡肝脏研究中心（PLRC）于2016年成立，是领导层高度热情的结果， 这与强大的机构支持和承诺的形式，从大学的资源， 匹兹堡医学中心（UPMC）和匹兹堡大学（UP）。PLRC真正代表了成功的合作伙伴关系 UPMC是医疗保健服务的先驱，UP是研究、发现、教育和 创新其中心使命是促进对细胞和分子基础的理解， 肝胆损伤和修复，PLRC汇集了一个非常强大的研究人员和临床医生小组 从事基础和转化肝脏研究，并为肝脏患者提供临床护理。在过去的两年里， PLRC汇集了80名研究人员和临床医生（49名正式成员），代表 UP和UPMC内的多个部门和机构，作为一个社区。这是由经常 网络，医生-基础科学家圆桌会议，研讨会和讲习班，以丰富环境， 有助于加强现有合作和建立新的伙伴关系。PLRC将自己组织成3个 高度功能性的科学兴趣小组（SIG）-再生医学，慢性肝病和肝脏 肿瘤发生-重叠的成员和定期安排的相互作用促进了科学的肥沃 通过一个相当新颖的丰富计划进行对话的环境。SIG圆桌会议允许经常性对话 在医生和科学家之间就精心挑选的主题进行合作，促进合作和更有意义的研究。 为了在PLRC研究人员的实验室中实现开创性和有影响力的科学，我们建立了3个高度集成的 生物医学研究核心和临床组成部分，提供最先进的和创新的服务，使 前沿研究和从实验室到临床的翻译。同样，PLRC确定新的调查人员，并通过 试点和可行性计划，支持他们的研究和开发作为独立的调查员，通过 除了科学支持外，还提供纵向指导和职业和专业发展活动。 通过机构支持的特别奖允许资助促进医生和基础科学家的团队科学项目 互动、技术开发和商业化。上述所有服务和功能都是针对 通过肝胆损伤和修复领域的研究，识别肝脏健康和疾病的复杂磨难 通过促进创新，跨学科，跨学科和多学科的合作研究，以产生可持续的影响 在一个行政机构的主持下， 核心事实上，PLRC的领导层利用了该研究所的许多现有优势，如CTSI，创新研究所 和库尔特项目，以及与匹兹堡大学癌症研究所等现有研究所建立的联盟 研究所，Starzl移植研究所和McGowan再生医学研究所扩大服务， PLRC为所有成员提供的好处，并最终改善他们的科学，翻译和商业化。 因此，最终，通过其综合服务和方案，PLRC的长期目标是促进 在肝胆病理生理学领域的有影响力的科学，并改善肝脏健康和护理，无论是在当地， 在全球

Abstract (from parent grant P30DK120531 entitled Pittsburgh Liver Research Center; PI: Monga, Satdarshan): The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician-basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting-edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.