Investigating Early Social Communication Trajectories of Late Talking Toddlers to Best Predict Language Outcomes for the NIH TALK Initiative

摘要 母公司R01 MH121364调查的目标是验证新的自动化 基于家长报告的在线筛查工具-社交(SoCo)检查-哪一个 整合了经过经验测试的通信延迟和自闭症谱系障碍(ASD)筛查项目。 家长调查招募了4000名9个月大的婴儿加入Baby Navigator。所有的家庭 在每次SoCo检查中筛查阳性的自闭症儿童，以及筛查阴性的对照组， 被邀请上传一段使用红旗系统观测编码的家庭观测视频 ASD(SORF)。家长资助涉及以下研究目标：目标1.研究心理测量学 SOCO检查临界点的特征和对诊断结果的综合；目的2.研究患者的运动轨迹 SOCO监测和筛查以预测自闭症诊断特征的严重程度；以及目标3.构建风险 基于多参数的算法来开发高效、经济高效的移动筛查应用程序 在婴儿中使用，易于在普通人群中部署。本次验证性研究的预期结果 将于年第一年开始展示在线监控和筛查系统的有效性 生活将准备好立即、快速、可扩展和可持续地在美国各地部署。 作为对NOT-DC-23-005的响应，本行政补充资料将建立在我们之前对LATH的研究基础上 说话者，并利用对父母补助金招募的儿童的评估，以帮助阐明 在这个样本中，晚说话儿童的早期社会交流轨迹和独特的语言结果。的 在家长津贴中招募和筛选的儿童，1,768人将在补贴期内2-4岁 项目期。我们将邀请300名儿童在2-4岁时参与补充随访评估 年龄。家长赠款中的评估将通过根据观察编码新的早期措施而得到加强 社会沟通和语言(OSCL)和观察响应性父母策略(ORPS)作为 使用从父母补助金收集的家庭观察的补充的一部分。这份副刊将 解决以下研究目标：目标1.研究编码OSCL的新措施与 来自家庭观察和在父母补助金中收集的措施的ORP-SOCO检查和 9-24个月的SORF；目标2。从9-24个月开始研究SOCO检查、SORF、OSCL和ORPS的轨迹 24个月来预测2-4岁儿童语言成绩的新指标；以及目标3.检查 社会文化人口学指标作为社会交流轨迹和语言结果的预测指标 晚说话的人。早期的社会沟通措施和社会文化指标以及这些新的 2-4年的语言测量将增强可用于表征差异轨迹以进行预测的数据 提高我们对说话迟缓儿童的发育后遗症的理解。 第1页，共1页

ABSTRACT The goal of the parent R01 MH121364 investigation is to validate the effectiveness of a new automated online screening tool based on parent report—the Social Communication (SoCo) CheckUp—which incorporates empirically-tested screening items for communication delay and autism spectrum disorder (ASD). The parent investigation is recruiting 4,000 infants who join Baby Navigator by 9 months of age. All families of children with a positive autism screen at each SoCo Checkup, and a comparison group with a negative screen, are invited to upload a video home observation that is coded using the Systematic Observation of Red Flags of ASD (SORF). The parent grant is addressing the following research aims: Aim 1. Study psychometric features of the SoCo Checkup cut-off and composite to diagnostic outcome; Aim 2. Study the trajectories of the SoCo surveillance and screening to predict severity of autism diagnostic features; and Aim 3. Construct a risk algorithm based on multiple parameters to develop an efficient, cost-effective mobile screening application for use in infants that is readily deployable in the general population. The expected outcomes of this validation study will demonstrate the effectiveness of an online surveillance and screening system beginning in the first year of life that will be ready for immediate, rapid, scalable, and sustainable deployment across the US. In response to NOT-DC-23-005, this administrative supplement will build upon our previous research on late talkers and capitalize on the evaluation of children recruited for the parent grant to contribute to elucidation of early social communication trajectories and unique language outcomes of late talking children in this sample. Of the children recruited and screened in the parent grant, 1,768 will be 2-4 years of age during the supplement project period. We will invite 300 children to participate in the supplement follow-up evaluations at 2-4 years of age. The evaluations in the parent grant will be enhanced by coding new early measures based on observation of social communication and language (OSCL) and observation of responsive parenting strategies (ORPS) as part of the supplement using the collected home observations from the parent grant. This supplement will address the following research aims: Aim 1. To study associations among new measures coding the OSCL and ORPS from the home observations and the collected measures in the parent grant—the SoCo CheckUp and SORF from 9-24 months; Aim 2. To study trajectories of the SoCo CheckUp, SORF, OSCL, and ORPS from 9- 24 months in predicting new measures of language outcomes at 2-4 years of age; and Aim 3. To examine sociocultural demographic indicators as predictors of social communication trajectories and language outcomes of late talkers. The early social communication measures and sociocultural indicators together with these new measures of language at 2-4 years will enhance data available to characterize differential trajectories to predict language outcomes and improve our understanding of the developmental sequalae for late talking children. Page 1 of 1