Molecular Transducers of Physical Activity Consortium Coordinating Center

项目摘要 体力活动分子传感器联合会(MoTrPAC)的成立是为了发现 耐力和阻力运动的分子传感器。联盟协调中心(CCC)， 由行政协调核心(ACC)、生物检疫库核心(BRC)、 运动干预核心(EIC)和数据管理、分析和质量控制(DMAQC)核心 提供专业知识、人员和信息技术(IT)解决方案来支持组织， 所有MoTrPAC的管理、规划、标准化、文档编制、监控、分析和报告 活动。这些职能需要与临床站点、临床前动物研究站点密切合作 (PASS)、辅助研究、生物信息学中心(BIC)、化学分析站点(CAS)以及 小组委员会和工作组(工作组)。联合国儿童基金会制定了旨在 将MoTrPAC调查人员的活动与数据和安全监测委员会提供的投入结合起来 (DSMB)、外部专家和美国国立卫生研究院(NIH)。Ccc由四位高素质的人领导。 PIS包括维克森林大学医学院(WFUSM)的米勒博士，他领导着DMAQC核心 并管理临床数据和安全相关活动，佛蒙特州大学(UVM)的特雷西博士负责- MoTrPAC指导委员会(SC)主席兼BRC负责人Rejeski博士 和埃瑟博士，他是威克森林大学ACC的负责人 佛罗里达州，并监督一个管理人员，这是管理整个联盟范围内的沟通的核心， 设立年会，并支持小组委员会和工作组。WFUSM是CCC的枢纽，拥有 DMAQC核心员工为所有其他组件提供项目管理、计算和分析支持 中央控制中心的。EIC还协助DMAQC核心开展与安全相关的活动，并与 DMAQC核心内的项目经理，负责支持与临床相关的职能，如手册 程序(MOP)、表型措施、干预者和评估员的认证以及现场访问。这个 CCC将继续使用创新的项目管理工具、编程和基于网络的跟踪 招聘和保留(R&R)、干预和实时评估。我们将充分利用 在成功协调、管理和领导大型长期多中心方面有出色的记录 涉及运动和其他干预措施的临床试验，以实现以下目标：(A)促进团队科学； (B)在研究中实行严谨、可再现性和透明度；(D)获取、管理、储存和分发 用于分析的生物样本；(E)进行和协调临床前运动研究；(F)共享资源；(G) 公布结果；和(H)领导多学科小组实施所应用的分析方法的最佳做法 到随机研究。中心将促进MoTrPAC在促进知识发展方面继续取得成功 认为运动的分子转导与公共健康有关。

Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to discover the molecular transducers of endurance and resistance exercise. The Consortium Coordinating Center (CCC), composed of the Administrative Coordinating Core (ACC), the Biospecimens Repository Core (BRC), the Exercise Intervention Core (EIC), and the Data Management, Analysis and Quality Control (DMAQC) Core provides expertise, personnel, and information technology (IT) solutions to support the organization, administration, planning, standardization, documentation, monitoring, analysis, and reporting of all MoTrPAC activities. These functions require working closely with the Clinical Sites, the Preclinical Animal Study Sites (PASS), Ancillary Studies, the Bioinformatics Center (BIC), the Chemical Analysis Sites (CAS), as well as subcommittees and working groups (WGs). The CCC has developed strategies and processes designed to integrate activities of MoTrPAC investigators with the input provided by the Data and Safety Monitoring Board (DSMB), outside experts, and the National Institutes of Health (NIH). The CCC is led by four highly qualified PIs including Dr. Miller at Wake Forest University School of Medicine (WFUSM) who leads the DMAQC Core and manages clinical data and safety-related activities, Dr. Tracy at the University of Vermont (UVM) who vice- chairs the MoTrPAC Steering Committee (SC) and leads the BRC, Dr. Rejeski who resides on the academic campus of Wake Forest University and leads the EIC, and Dr. Esser who leads the ACC at the University of Florida and oversees an administrative staff that is the core for managing Consortium-wide communications, setting-up annual meetings, and supporting subcommittees and WGs. WFUSM is the hub of the CCC, with the DMAQC Core staff providing project management, computing, and analytical support for all other components of the CCC. The EIC also assists the DMAQC Core with safety-related activities and is highly integrated with project managers within the DMAQC Core for supporting clinic-related functions such as Manuals of Procedures (MOPs), phenotypic measures, certification of interventionists and assessors, and site visits. The CCC will continue to employ innovative project management tools, programming, and web-based tracking of recruitment and retention (R&R), interventions, and assessments in real-time. We will capitalize on the outstanding track record in successfully coordinating, managing, and leading large long-term multicenter clinical trials involving exercise and other interventions to accomplish the following: (a) facilitate team science; (b) implement rigor, reproducibility, and transparency in research; (d) acquire, manage, store, and distribute biological samples for analysis; (e) conduct and coordinate preclinical exercise studies; (f) share resources; (g) publish results; and (h) lead multidisciplinary teams to implement best-practices for analytical methods applied to randomized studies. The CCC will facilitate the continued success of MoTrPAC in advancing knowledge regarding the molecular transducers of exercise as related to public health.