Introducing CI/CD Technologies to Optimize Software Development in Reactome

项目摘要/摘要 我们寻求对反应堆核心运营资金的补充支持 人类生物途径和过程的知识库。Reactome是一个精心策划的 知识库以开放访问资源的形式在线提供，可免费使用 由生物和生物医学研究界的所有成员重新分配。它被用来 由临床医生、基因组学研究人员和分子生物学家解释高密度脂蛋白的结果 吞吐量实验研究，由寻求开发新算法的生物信息学家进行 从基因组研究中挖掘知识，以及系统生物学家建立预测模型 正常途径和疾病变异途径。我们的策展人，博士级别的科学家，与 社区内的独立调查人员收集机器可读的描述 人类的生物学途径。在发布之前，会对路径进行检查和同行评审 确保其事实的准确性和与数据模型的一致性。一种证据追踪系统 确保主要文献支持所有断言。Reactome使用社区标准 受控词汇表和本体，以提高资源间的互操作性。路径 定期审查和更新。反应组路径可在我们的网站上找到 内部和第三方分析工具可以浏览、下载和访问。这个 该项目在文献中被高度引用，已被反复使用，取得了重大的生物学意义 和临床发现，并被整合到许多高影响力的信息学工具和 资源。 在过去的二十年里，Reactome开发了一款复杂的软件 生态系统。这个生态系统由各种组成部分组成，包括管理、质量 保证/质量控制、数据分析和可视化、发布和导出。我们的初选 Parent Reactome赠款的重点是将基于GWT的旧Web应用程序升级到 现代的基于角度的应用程序，将独立的基于Java的策展工具移植到Web上，以及 将我们的内部策展人数据库从MySQL迁移到Neo4j。有了这个后盾 补充拨款，我们的目标是引入现代持续集成/持续 在我们的软件开发过程中部署(CI/CD)技术。这将使我们能够 更高效地更新现有组件并无缝集成新组件。我们还计划 采用LinkML这一现代知识图表编辑工具来管理我们的数据 模特。我们将替换过时的多步数据模型更新协议，它依赖于Perl 和Protege，并且需要对多个组件进行繁琐的手动编辑。在…的帮助下 通过这项补充拨款，我们将使我们的软件开发更加精简和高效。

Project Summary/Abstract We seek supplemental support to the core operating funding for the Reactome Knowledgebase of human biological pathways and processes. Reactome is a curated knowledgebase available online as an open access resource that can be freely used and redistributed by all members of the biological and biomedical research communities. It is used by clinicians, genomics researchers, and molecular biologists to interpret the results of high- throughput experimental studies, by bioinformaticians seeking to develop novel algorithms for mining knowledge from genomic studies, and by systems biologists building predictive models of normal and disease variant pathways. Our curators, Ph.D.-level scientists, work closely with independent investigators within the community to assemble machine-readable descriptions of human biological pathways. Pathways are checked and peer-reviewed prior to publication to ensure its factual accuracy and compliance with the data model. A system of evidence tracking ensures that the primary literature supports all assertions. Reactome uses community-standard controlled vocabularies and ontologies to increase interoperability across resources. Pathways are reviewed and updated regularly. Reactome pathways are available on our website for browsing, downloading, and are accessible to in-house and third-party analysis tools. The project is highly cited in the literature, has been used repeatedly to make significant biological and clinical discoveries, and is incorporated into many high-impact informatics tools and resources. Over the past two decades, Reactome has developed a sophisticated software ecosystem. This ecosystem comprises various components for curation, quality assurance/quality control, data analysis and visualization, release, and export. Our primary focus in the parent Reactome grant is to upgrade the old GWT-based web application to a modern Angular-based app, port the standalone Java-based curator tool to the web, and migrate our internal curator database from MySQL to Neo4j. With the backing of this supplemental grant, we aim to introduce modern Continuous Integration/Continuous Deployment (CI/CD) technologies into our software development process. This will allow us to update existing components more efficiently and integrate new ones seamlessly. We also plan to adopt LinkML, a modern tool for editing knowledge graph schemas, to manage our data model. We will replace the outdated multi-step data model update protocol, which relies on Perl and Protege and requires tedious manual editing across multiple components. With the help of this supplemental grant, we will make our software development more streamlined and efficient.