A pilot study of ambulatory Heart Rate Variability Biofeedback for substance use disorder

项目摘要/摘要 在物质使用障碍的早期康复中，日常经历的负面情绪和与物质相关的线索 通常作为物质使用的触发物，看起来是自动的，绕过了患者的认知计划和 有意识的意图不使用。一线认知-行为物质使用障碍的中心目标 治疗是加强情感和认知控制，以提高个人超越冲动的能力 使用物质。然而，被物质使用障碍损害的自动生理过程与 内部情感状态和环境线索，破坏努力的认知控制和胜过竞争目标 以避免使用物质。这种组合破坏了一线治疗和 介绍了治疗辅助物的必要性，这些辅助物可能会支持更好地调节情绪和增强认知能力 控制力。一种潜在的治疗辅助手段是心率变异性生物反馈。这种多样性的目标是 补充申请是为了支持Sara Mei的培训和职业发展。她长期的职业生涯 目标是建立一个独立的研究计划，专注于识别和监测 利用移动技术改善准时制物质使用的情感和心理生理机制 可推广到广泛人群的干预和预防方法。研究计划 通过提供一种工具来增加她在以下方面的成瘾研究专业知识，从而补充了指导目标：1) 心理生理机制和方法，2)动态评估方法，3)高级统计学 技术，以及4)手稿写作和科学工作的传播。这一多样性补充将 为应聘者提供专业培训和受保护的研究时间，以增强其研究能力 并为作为一名富有成效的研究人员的职业发展提供机会。候选人将加入 家长资助的研究团队作为研究助理，并在 大卫·埃迪博士和家长格兰特的合作团队将获得建立她所需的专业知识 新的研究计划。最终，这项培训将使候选人做好准备，建立一系列 整合情感和心理生理的动态评估的独立研究 复发风险的机制。多样性副刊将允许候选人将她的时间奉献给 拟议的活动旨在加强她作为调查员的研究能力和独立性，这将 从而增加在成瘾领域进行研究的代表不足的研究人员的数量 研究。此外，这一补充与NIH增加和保持强劲的 一批研究人员，以满足国家的临床研究需求。

PROJECT SUMMARY/ABSTRACT In early substance use disorder recovery, everyday experiences of negative affect and substance-related cues often serve as triggers for substance use that appear automatic and bypass patients’ cognitive plans and conscious intentions not to use. A central goal of frontline cognitive-behavioral substance use disorder treatments is to strengthen affective and cognitive control to increase individuals’ ability to override impulses to use substances. Yet, automatic physiological processes compromised by substance use disorder interact with internal affective states and environmental cues to undermine effortful cognitive control and outcompete goals to avoid substance use. This combination undermines the potential efficacy of frontline treatments and introduces the need for treatment adjuncts that might support better regulate affect and bolster cognitive control. One potential treatment adjunct is Heart Rate Variability Biofeedback. The goal of this diversity supplement application is to support the training and career development of Sara Mei. Her long-term career objective is to establish an independent program of research that focused on identifying and monitoring affective and psychophysiological mechanisms of substance use with mobile technology to improve just-in-time intervention and prevention methods generalizable to a wide range of populations. The research plan complements the mentoring goals by providing a vehicle for increasing her addiction research expertise in: 1) psychophysiological mechanisms and methods, 2) ambulatory assessment approaches, 3) advanced statistical techniques, and 4) manuscript writing and the dissemination of scientific work. This diversity supplement will support the candidate with specialized training and protected research time to enhance her research capability and provide opportunities for career development as a productive researcher. The candidate will join the research team of the parent grant as a research assistant and conduct the research under the supervision of Dr. David Eddie, PhD, and the parent grant’s team of Co-Is to gain the expertise needed to establish her nascent program of research. Ultimately, this training will prepare the candidate to establish a line of independent research that integrates ambulatory assessment of affective and psychophysiological mechanisms of relapse risk. The diversity supplement will allow the candidate to dedicate her time to the proposed activities aimed at enhancing her research capability and independence as an investigator, which will thereby increase the number of underrepresented research faculty conducting research in the field of addiction research. Moreover, this supplement is consistent with NIH's goal of increasing and maintaining a strong cohort of investigators to address the nation's clinical research needs.