Wyoming IDeA Networks for Biomedical Research Excellence Phase 4

项目总结 怀俄明州IDEA生物医学研究卓越网络INBRE旨在建立一个全州范围的网络 以表彰生物医学研究和卓越。具体来说，WY INBRE的目标是：1)建立多学科 以科学为重点的研究网络将加强生物医学研究的专门知识和基础设施 怀俄明大学及其伙伴机构；2)建立怀俄明大学的研究基地和能力 怀俄明州及其合作机构为教师、博士后研究员和研究生提供研究支持 学生；3)为本科生提供研究机会；4)提高科学技术水平 对该州劳动力的了解；以及5)扩大怀俄明州整个西部理念的研究机会 地区。与这些目标一致，本行政副刊(非-GM-23-034)旨在回答 重要的多学科生物医学研究问题，使用互补的、尖端的方法。我们的 团队科学方法将结合Nicole Bedford博士的专业知识和不同的学科观点 (行为神经科学)、Danielle Bruns博士(心脏衰老)和Emily Schmitt博士(昼夜生物学)。 我们将共同利用创新技术解决一个复杂的基础/翻译研究问题。我们的目标是 目的：了解老年人群中发病率较高的老年夜尿症的发病机制。 具体地说，我们将剖析夜尿的神经行为和心肾昼夜节律机制。最后的, 我们将测试计时锻炼对夜尿症表型的潜在挽救作用--一种新的治疗方法 巨大的翻译潜力。这一目标的成功实现需要团队科学的努力。 总之，这项提案不仅将解决老龄化人口中的重大生物医学问题，而且还将解决我们强大的 合作小组将为外部资金申请生成初步数据。在本报告中提出的工作 补编还包括研究生和本科生研究助理的贡献，他们是 有必要扩大怀俄明州的生物医学研究能力。

PROJECT SUMMARY The Wyoming IDeA Networks for Biomedical Research Excellence INBRE aims to establish a statewide network for biomedical research and excellence. Specifically, WY INBRE aims are to: 1) build the multidisciplinary research network with scientific foci that will strengthen biomedical research expertise and infrastructure at the University of Wyoming and its partner institutions; 2) build the research base and capacity of the University of Wyoming and its partner institutions by providing research support to faculty, postdoctoral fellows and graduate students; 3) provide research opportunities for undergraduate students; 4) enhance the science and technology knowledge of the state's workforce; and 5) expand Wyoming research opportunities across the Western IDeA Region. Consistent with these goals, this Administrative Supplement (NOT-GM-23-034) aims to answer significant multidisciplinary biomedical research questions using complementary, cutting-edge approaches. Our team science approach will combine the expertise and diverse disciplinary perspectives of Dr. Nicole Bedford (behavioral neuroscience), Dr. Danielle Bruns (cardiac aging), and Dr. Emily Schmitt (circadian biology). Together, we will address a complex basic/translational research question using innovative technology. We aim to understand the mechanisms of age-related nocturia, a condition with high morbidity in the aging population. Specifically, we will dissect the 1) neurobehavioral and 2) cardiorenal circadian mechanisms of nocturia. Last, we will 3) test the potential rescue of the nocturia phenotype by chronotimed exercise – a novel therapy with significant translational potential. Successful accomplishment of this goal necessitates a team science effort. Together, the proposal will not only address significant biomedical questions in aging populations, but our strong collaborative team will generate preliminary data for extramural funding applications. The work proposed in this supplement also includes the contributions of graduate and undergraduate research assistants, who are necessary to expand biomedical research capacity in Wyoming.