Administrative Core

摘要慢性鼻窦炎综合研究项目2(CRISP2)是 流行病学家、耳鼻喉科医生、过敏学家和免疫学家，其中高度合作的研究 提出了更好地理解疾病异质性的分子和细胞机制，以及这些 机制转化为临床表型、自然病史和长期结果。该节目的重点是 尤其要注意无鼻息肉的CRS(CRSsNP)，这是一种高度流行但却鲜为人知的表型 我们目前理解的立场。CRISP2的另一个焦点是对机制进行批判性评估 以及患者同时患有CRS和哮喘等肺部疾病的共病情况的后果 或者是支气管扩张症。还有一个主题是，在我们理解为什么女性比 比男性受CRS的影响更大。为了实现这些目标，组成 CRISP2研究团队创新了发病机制和疾病研究的新方法和新方法 流行病学，最重要的是，将这两个学科合并，将机制与症状联系起来， CRS的严重程度、病史和转归。 行政核心(核心A)的主要职能是提供行政支助 为项目的大力整合努力，促进沟通和数据共享，催化 出版和报告工作结果，确保慢性鼻窦炎综合 研究计划-2(CRISP2)促进有效的培训职能和组织咨询委员会和 CRISP2参与中心和调查人员的定期会议。核心A还负责 为该计划准备进度报告，并监督各机构的法规遵从性 和政府机构。核心A将在促进协同和高级协作方面发挥核心作用 程序中的交互。我们已将这些职能和其他职能组织成以下具体目标：1. 为CRISP2提供中央行政服务，包括监督资金分配、管理 行政办公室，促进在预算、人事或科学方向上发生的变化，监督 编写进度报告并保证适当遵守NIH、NU、UC、 G/JHU以及地方、州和联邦机构。行政团队是Schlemer博士(PI)，Valarie Thomas女士 以及Seleta Nichols女士(行政人员)和Alfred Rademaker博士(生物统计学家)。2.)为了方便 在CRISP2中进行沟通，并组织一个咨询委员会。CRISP2将每季度召开四次会议 该办公室将于明年提供服务，并将维持一个基于互联网的云通信系统。3.)传播由以下机构做出的发现 CRISP2.核心A将促进手稿的准备和网站的维护。4.)鼓励培训。 核心A将支持一项正在进行的年轻学者资助计划。5.)促进跨学科研究。 核心A将促进参与CRISP2的学科和个人调查人员之间的互动。

ABSTRACT The Chronic Rhinosinusitis Integrative Studies Program 2 (CRISP2) is an integrated program of epidemiologists, otolaryngologists, allergists and immunologists in which highly collaborative studies are proposed to better understand the molecular and cellular mechanisms of disease heterogeneity and how these mechanisms translate into clinical phenotypes, natural history and long term outcomes. The program focuses particular attention to CRS without nasal polyps (CRSsNP), a highly prevalent and yet obscure phenotype from the standpoint of our current understanding. Another focus of CRISP2 is to critically evaluate the mechanisms and consequences of comorbid conditions in which patients have both CRS and lung disease such as asthma or bronchiectasis. Yet another theme is to make inroads in our understanding of why women are more significantly impacted by CRS than men. In order to achieve these goals, the investigators that comprise the CRISP2 study team have innovated new assays and approaches to cutting edge studies of pathogenesis and epidemiology and, most importantly, have merged these two disciplines to relate mechanisms to symptoms, severity, history and outcomes of CRS. The Administrative Core (Core A) has as its main functions the goals of providing administrative support for the vigorous integrative efforts of the program, facilitating communication and data sharing, catalyzing publications and reporting of the findings of the work, ensuring that the Chronic Rhinosinusitis Integrative Research Program-2 (CRISP2) promotes an effective training function and organizing the advisory board and the regular meetings of the CRISP2 participating centers and investigators. Core A is also responsible for the preparation of progress reports for the program and overseeing regulatory compliance with various institutional and governmental agencies. Core A will play a central role in promoting synergy and advanced collaborative interactions in the program. We have organized these and other functions into the following specific aims: 1.) To provide central administrative services for CRISP2, including oversight of funds distribution, managing the administrative office, facilitating changes that occur in budget, personnel or scientific direction, overseeing preparation of progress reports and assurance of appropriate compliance with directives from the NIH, NU, UC, G/JHU and local, state and federal agencies. The administrative team is Dr. Schleimer (PI), Ms. Valarie Thomas and Ms. Seletta Nichols (administrators) and Dr. Alfred Rademaker (biostatistician). 2.) To facilitate communications in CRISP2 and organize an advisory board. CRISP2 will have four quarterly meetings each year and will maintain an internet-based cloud communications system. 3.) To disseminate discoveries made by CRISP2. Core A will facilitate manuscript preparation and maintenance of a website. 4.) To encourage training. Core A will support an ongoing grant program for young scholars. 5.) To promote interdisciplinary research. Core A will facilitate interactions of the disciplines and individual investigators that are involved in CRISP2.