NOVEL SKIN PORT DEVICE FOR BLOOD GLUCOSE SENSING

糖尿病是一种慢性疾病，如果不加以控制， 引起血糖水平的剧烈波动。为了 维持正常的血糖水平，必须监测血糖 经常在一天中。我们建议设计和开发一个 新型近红外皮肤端口传感器（NIR-SPS），以允许非 有创血糖监测。目前，只有侵入性 血糖监测器是市售的，其需要 每个阅读都要进行手指针刺。近红外吸收 光谱学正在开发中，以非侵入性地量化血液 葡萄糖这种方法的主要障碍包括皮肤光学 其可由于光路中的不确定变化而改变光路 皮肤的散射和吸收特性， 种族之间的差异以及由于 温度和探针压力。我们提出的NIR-SPS将消除 通过提供无表皮窗口的表皮光学效果将 提供固定的几何路径长度，并将最小化 温度和压力变化。新的NIR-SPS将是 在体外设计、开发和测试以优化波长并 路径长度将在猪动物模式下进行中试实验， 评估愈合时的光学性能，并监测 葡萄糖

Diabetes mellitus is a chronic disease which, if unregulated, can give rise to wild fluctuations in blood glucose levels. In order to maintain normal glucose levels, blood glucose must be monitored frequently throughout the day. We propose to design and develop a novel near-infrared skin port sensor (NIR-SPS) to allow for non- invasive monitoring of blood glucose. Currently, only invasive blood glucose monitors are commercially available, which requires a finger stick for each reading. Near-infrared (NIR) absorption spectroscopy is under development to non-invasively quantify blood glucose. Major obstacles to this approach include the skin optics which can alter the optical path due to uncertain variations in scattering and absorption properties of the skin both within and between ethnic races as well a errors due to variation in temperature and probe pressure. Our proposed NIR-SPS will eliminate the effect of skin optics by providing a skinless window, will provide a fixed geometric path length, and will minimize temperature and pressure variations. The novel NIR-SPS will be designed, developed and tested in vitro to optimize wavelength and pathlength. Pilot experiments will be done in a pig animal mode to assess optical performance with healing and monitor changes in glucose.