Mechanisms of glucocorticoid resistance in acute lymphoblastic leukaemia

糖皮质激素是治疗儿童急性淋巴细胞性白血病(ALL)的一种非常有效的药物，但部分患者对治疗反应差，复发时表现出耐药性。糖皮质激素抵抗的临床相关机制尚不清楚，主要是由于缺乏合适的实验模型。该项目将揭示儿童白血病耐药的新机制，并导致新的治疗策略来改善结果。

Glucocorticoids are extremely active drugs used in the treatment of childhood acute lymphoblastic leukaemia (ALL), yet a proportion of patients respond poorly to therapy and exhibit resistance at relapse. Clinically relevant mechanisms of glucocorticoid resistance are poorly understood, principally due to lack of appropriate experimental models. This project will reveal novel mechanisms of drug resistance in childhood leukaemia and lead to novel therapeutic strategies to improve outcome.