Studying the interaction of Reelin deficiency and environmental factors in the development of schizophrenia using animal behavioural models

使用动物行为模型研究 Reelin 缺陷与环境因素在精神分裂症发展中的相互作用

• 批准号: nhmrc : 1004129
• 负责人: A/Pr Jeffrey Craig
• 金额: $ 29.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studying-interaction-reelin-behavioural-models/108999
• 关键词: Studying; interaction; Reelin; deficiency; environmental

Schizophrenia is caused by an interaction of genetic predisposition and environmental risk factors such as stress or drug abuse. Reelin is a protein involved in the normal development of the brain but its levels are markedly reduced in schizophrenia. We will use mice with low levels of reelin in their brain and assess the effect of environmental stress and drugs of abuse. These studies could elucidate gene-environment interaction in schizophrenia and lead to new treatment strategies.

精神分裂症是由遗传倾向和环境危险因素（例如压力或药物滥用）相互作用引起的。 Reelin 是一种参与大脑正常发育的蛋白质，但其水平在精神分裂症患者中显着降低。我们将使用大脑中 reelin 水平较低的小鼠来评估环境压力和滥用药物的影响。这些研究可以阐明精神分裂症中基因与环境的相互作用，并带来新的治疗策略。