Mental Health Across Generations: pre-and post conception predicators of early life risks

跨代心理健康：早期生命风险的受孕前和受孕后预测因素

• 批准号: nhmrc : 437015
• 负责人: A/Pr Jeffrey Craig
• 金额: $ 44.42万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mental-health-generations-life-risks/101116
• 关键词: Mental; Health; Across; Generations; pre

In 2003, mental illnesses were among the ten leading causes of disease burden in Australia, accounting for 13% of the total burden of disease, according to the Australian Institute of Health and Welfare. Mental health problems and mental illness are among the greatest causes of disability, diminished quality of life, and reduced productivity. People affected by mental health problems often have high levels of morbidity and mortality, experiencing poorer general health and higher rates of death from a range of causes, including suicide. These conditions are significant in terms of prevalence and disease burden, and have far-reaching impacts for families, carers and others in the community. Mental health problems commonly cluster in families. However, few studies have previously been able to investigate the range of ways in which mental disorders may pass from one generation to another. Further, evidence suggests that influences that arise prior to conception may have major effects on early life risks such as development in utero, birth outcomes and early maternal infant bonding. Mental Health across Generations: Pre- and post-conception predictors of early life risks is a unique study that will examine antenatal maternal mental health and risk behaviours during pregnancy. The study will also examine the links between prior maternal mental health and later birth outcomes, and post natal maternal infant bonding. The risk processes to be tested will include genetic, epigenetic (changes in gene expression), physiological and psycho-social parameters.

根据澳大利亚健康和福利研究所的数据，2003年，精神疾病是澳大利亚疾病负担的十大主要原因之一，占疾病总负担的13%。心理健康问题和精神疾病是造成残疾、生活质量下降和生产力下降的最大原因之一。受精神健康问题影响的人往往有很高的发病率和死亡率，总体健康状况较差，各种原因（包括自杀）造成的死亡率较高。就患病率和疾病负担而言，这些情况意义重大，并对家庭、护理人员和社区其他人产生深远影响。心理健康问题通常集中在家庭中。然而，以前很少有研究能够调查精神障碍可能从一代传给另一代的方式范围。此外，有证据表明，怀孕前产生的影响可能对早期生命风险产生重大影响，如子宫内发育、出生结果和早期母婴关系。跨代心理健康：早期生命风险的孕前和孕后预测因素是一项独特的研究，将检查产前孕产妇心理健康和怀孕期间的风险行为。该研究还将调查产妇之前的心理健康与后来的分娩结果以及产后母婴关系之间的联系。要检测的风险过程将包括遗传、表观遗传（基因表达的变化）、生理和心理社会参数。