Genome-wide epigenetic analysis of Childhood Acute Lymphoblastic Leukaemia

儿童急性淋巴细胞白血病的全基因组表观遗传学分析

• 批准号: nhmrc : 607306
• 负责人: A/Pr Jeffrey Craig
• 金额: $ 27.37万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genome-wide-epigenetic-lymphoblastic-leukaemia/98869
• 关键词: Genome; wide; epigenetic; analysis; Childhood

Of all cancers in children, Acute Lymphoblastic Leukaemia is the most common. To date, the causal mechanism(s) for leukaemia in children remain unclear. Although 5-year event-free survival rates are relatively high (up to 80%) it is still unclear why children expected to survive with a good prognosis, succumb to the disease. Therefore, there is still a need to further refine current diagnosis and prognosis parameters that will together lead to improved outcomes to children with leukaemia.

在所有儿童癌症中，急性淋巴细胞白血病是最常见的。迄今为止，儿童白血病的因果机制仍不清楚。虽然5年无事件生存率相对较高（高达80%），但仍不清楚为什么预期预后良好的儿童会死于该病。因此，仍然需要进一步完善目前的诊断和预后参数，共同改善白血病儿童的预后。