THE CYCLE OF OBESITY: Two generations of a pregnancy cohort to investigate obesity epigenetics

肥胖周期：两代妊娠队列研究肥胖表观遗传学

• 批准号: nhmrc : 1059711
• 负责人: A/Pr Jeffrey Craig
• 金额: $ 74.53万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cycle-obesity-generations-obesity-epigenetics/454776
• 关键词: CYCLE; OBESITY; Two; generations; pregnancy

Obesity has increased 3-5 fold in the last fifty years, overtaking smoking as the greatest killer. In recent history, each generation has experienced greater amounts of obesity and at younger ages. Being exposed in the womb to mother’s obesity transmits the risk to the child, possibly by changing our epigenetic profile and how our DNA code is read. We need to break this vicious cycle. This study is a world first, investigating 2 generations with respect to obesity and epigenetic profiles.

在过去的50年里，肥胖症增加了3-5倍，超过吸烟成为最大的杀手。在近代史上，每一代人都经历了更多的肥胖症，而且年龄更小。在子宫中暴露于母亲的肥胖会将风险传递给孩子，可能是通过改变我们的表观遗传学特征和我们DNA密码的读取方式。我们需要打破这种恶性循环。这项研究是世界上第一次，调查了两代人的肥胖和表观遗传学特征。