BABOON RESEARCH RESOURCE PROGRAM

这份P40拨款申请建议扩大和增强Babon 俄克拉荷马大学健康科学中心资源中心 (OUHSC)OUHSC已经维护了一个狒狒设施40多年了。我们的 从一个小部门运作到一个项目的狒狒研究计划 支持三所卫生学院的研究人员 科学中心，俄克拉荷马州的两个非营利性研究机构 卫生中心校区，三所主要大学医学教学和 俄克拉荷马州的研究机构和10个医疗中心 遍布全美。狒狒正被用于一种日益增长的 生物医学研究的数量，但它们的可用性有限；它们是 在现有的灵长类繁育计划和进口中代表性不足 来自野外的是昂贵的、困难的，而且为了健康而受到严格的监管 理由。由于OUHSC已成为可靠的狒狒资源，我们有 认识到有必要扩大和提高生产率。 我们建议通过增加我们的员工和 建造一个新的繁育设施。该设施由大学提供支持 资金，将位于美国农业部7000英亩的草地研究 车站位于俄克拉何马州埃尔里诺附近OUHSC以西30英里处。那里, 我们将提供一个更加自然的环境来饲养狒狒。 在大型户外畜栏中繁殖的群体。一个非人类的加入 灵长类生殖行为学家和兽医生精专家将 提供专业知识帮助提高我们的工作效率。灵长类动物 行为学家将对狒狒的繁殖行为进行研究 以及生物学，它将识别任何繁殖问题并改善 他们。她还将指导一个环境浓缩项目。我们会 表征群体的病毒状态，并形成一个核心 将建立无特定病原体的狒狒繁育计划 在俄克拉何马州立大学兽医学院 俄克拉何马州斯蒂尔沃特。 这项研究资源计划将加强和扩大非人类 OUHSC的生物医学和行为研究，刺激增加 区域研究机构之间的合作，建立OUHSC 作为国家认可的狒狒供货商作为研究对象。

This P40 grant application proposes to expand and enhance the Baboon Resource Center at the University of Oklahoma Health Sciences Center (OUHSC). The OUHSC has maintained a baboon facility for over 40 years. Our baboon research program from a small department operation to a program that supports research investigators in three colleges of the Health Sciences Center, two non-profit research institutions on the Oklahoma Health Center Campus, the three main university medical teaching and research institutions in the State of Oklahoma, and 10 medical centers located throughout the United States. Baboons are being used in a growing number of biomedical studies, yet their availability is limited; they are under-represented in existing primate breeding programs and importation from the wild is expensive, difficult, and strictly regulated for health reasons. As the OUHSC has become a reliable baboon resource, we have recognized a need to expand and improve productivity. We propose to enhance our research program by increasing our staff and creasing a new breeding facility. The facility, supported by University funds, will be located at the 7,000 acre USDA Grazinglands Research Station located 30 miles west of the OUHSC near El Reno, Oklahoma. There, we will provide a more naturalistic environment for maintaining the baboon breeding colony in large outdoor corrals. The addition of a non-human primate reproductive behaviorist and a veterinary theriogenologists will provide expertise to assist in increasing our productivity. The primate behaviorist will conduct research studies on baboon reproductive behavior and biology which will identify any reproduction problems and ameliorate them. She will also direct an environmental enrichment program. We will characterize the viral status of the colony and develop a nucleus of baboons for a specific-pathogen-free breeding program, to be established at the Oklahoma State University College of Veterinary Medicine in Stillwater, Oklahoma. This research resource program will strengthen and expand non-human biomedical and behavioral research at the OUHSC, stimulate increased cooperation among regional research institutions, and establish the OUHSC as a nationally-recognized provider of baboons as a research subject.