Femtosecond-Pulse Laser for Biology & Medicine

描述(申请人提供)：本研究的长期目标 是紧凑型、坚固耐用且用户友好的飞秒脉冲激光器的开发 在生物学和医学中应用的资源。例子包括多光子 显微镜、光学相干层析成像和飞秒彗星 做手术。仅在过去的几年里，生物学和医学的研究人员就 展示了飞秒脉冲激光器的许多新应用。进阶 如果这些要在国外被接受，就必须开发激光光源 专门的研究实验室。这些资源将为研究人员提供 生物和生物物理科学更多地获得新技术，同时 增强和拓展自身能力。 其主要目标是开发高能光纤激光器。由于最近 进步，开发具有以下能力的短脉冲信号源 超越块状固体激光器是现实的。纤维和半导体 提供完全集成设备的可能性，这将是必需的 以实现新的短脉冲技术的广泛应用。 这项工作的第二个重点将是开发和应用 支持生物成像技术的测量能力。这将是 包括对半导体纳米晶作为荧光团的评估 多光子显微镜。 开发新的和/或增强的可视化和 从分子到宏观层面对组织的影响已经 明显的健康益处和类似或更大的影响可以预期在 未来。

Description (provided by applicant): The long-term objective of this research is the development of compact, robust, and userfriendly femtosecond-pulse laser sources for applications in biology and medicine. Examples include multi-photon microscopy, optical coherence tomography imaging, and femtosecond comeal surgery. In the last few years alone, researchers in biology and medicine have demonstrated numerous new applications of femtosecond-pulse lasers. Advanced laser sources must be developed if these are to find acceptance outside specialized research laboratories. Such sources will provide researchers in the biological and biophysical sciences much greater access to new techniques while enhancing and expanding their capabilities. The primary aim is to develop high-energy fiber lasers. As a result of recent advances, the development of short-pulse sources with capabilities that will exceed those of bulk solid-state lasers is realistic. Fibers and semiconductors offer the possibility of completely integrated devices, which will be required for new short-pulse techniques to attain widespread use. A secondary focus of this work will be the development and application of measurement capabilities in support of biological imaging techniques. This will include the assessment of semiconductor nanocrystals as fluorophores in multi-photon microscopy. The development of new and/or enhanced capabilities for visualizing and affecting tissue at levels ranging from molecular to macroscopic has had obvious health benefits and similar or greater impact can be expected in the future.