Wireless EEG and Attention Evaluation System for ADHD

这项建议旨在开发一种可移动的、无线的神经心理评估系统，用于对注意力缺陷障碍(ADD)和注意缺陷多动障碍(ADHD)儿童进行定量筛查和评估。该系统将能够采集和分析脑电(脑电图仪)、事件相关脑电电位和注意力变量，以进行客观的ADHD筛查、诊断和药物疗效评估。根据该计划开发的神经心理评估系统本质上是将多通道无线EEG/ERP采集和分析设备与基于听觉的注意力连续操作测试(CPT)相结合。该组合系统将能够被精神病学家和神经病学家用于一些短期测试方案中，这些测试方案将允许检测出 同时排除嗜睡和其他神经缺陷(如癫痫发作)。拟议的系统将基于克利夫兰医疗设备公司(CMDI)最先进的微型生物遥测技术及其新型生物信号处理和解释软件而开发。特别是，该系统将利用CMDI正在进行的无线警报监测项目，并将使该系统适应ADHD人群。在第一阶段，开发的ADHD系统将用于30名ADHD患者和15名年龄匹配的正常受试者的广泛临床试验。

This proposal intends to develop an ambulatory, wireless, neuropsychological assessment system for quantitative screening and evaluation of children with attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD). The proposed system would be capable of acquiring and analyzing EEG (Electroencephalograph), ERP (Event-related EEG potential), and attention variables for an objective ADHD screening, diagnosis, and assessment of the effectiveness of medication. The neuropsychological assessment system to be developed under this program essentially combines a multi-channel wireless EEG/ERP acquisition and analysis device with an auditory-based continuous performance test (CPT) of attention. The combined system will be capable of being utilized by the psychiatrists and neurologists in a number of short-duration test protocols that will allow for detection of behavioral and neurological signs of ADHD while ruling out sleepiness and other neurological deficiencies (such as epileptic seizures). The proposed system will be developed based on the Cleveland Medical Devices Inc. (CMDI) state-of-the-art miniature bio-telemetry technology along with its novel bio-signal processing and interpretation software. In particular, the system will take advantage of the CMDI on-going wireless alertness monitoring project and will adapt that system for the ADHD population. During Phase I, the developed ADHD system will be used in an extensive clinical trial with 30 ADHD patients and 15 age-matched normal subjects.