Breaking the Barrier to an HIV Vaccine

项目总结 艾滋病毒仍然是上个世纪最严重的人畜共患传染病，有3600万人死亡，另有3700万人死亡 被感染了。即使在今天，全球每天仍有近2000人死于艾滋病毒/艾滋病。药物正在减少这种影响 艾滋病毒在人体内的传播，并将病毒传播给他人。然而，在大流行40年后，那里 是没有疫苗的。有效的艾滋病毒疫苗仍然是我们彻底结束艾滋病毒/艾滋病大流行的唯一希望 全。HIV疫苗主要是在猕猴身上开发的，尽管这种HIV感染的灵长类模型已经 有很多限制。在这里，我们探索一种新的艾滋病毒感染动物模型，该模型概括了 艾滋病毒急性感染并在建立潜伏的病毒库。我们开发了必要的工具，以使 这为长期寻求的艾滋病毒疫苗开发模式奠定了基础。这种新的动物模型将提供完美的 研究免疫相关保护的系统，针对不同HIV-1的交叉保护的广度 亚型，并测试和开发候选疫苗。

PROJECT SUMMARY HIV remains the most consequential zoonosis of the last century, with 36 million fatalities and another 37 million infected. Even today, almost 2,000 people per day die of HIV/AIDS globally. Medications are reducing the effects of HIV on the human body and transmission of the virus to others. However, 40 years into the pandemic, there are no vaccines. Effective HIV vaccines remain our only hope of ending the HIV/AIDS pandemic once and for all. HIV vaccines are mostly developed in macaque monkeys, although this primate model of HIV infection has many limitations. Here, we explore a new animal model for HIV infection that recapitulates all key milestones in HIV acute infection and in the establishment of the latent viral reservoir. We develop the tools necessary to turn this into the long-sought model for HIV vaccine development. This new animal model will provide the perfect system to study the immune correlates of protection, the breadth of cross-protection against different HIV-1 subtypes, and to test and develop vaccine candidates.