Origins of Renal Physiology

项目摘要/摘要 MDI生物实验室寻求NIDDK R25支持，用于第14至18届年度产品 为期一周的肾脏研究员课程，肾脏生理学起源。课程将于2023年8月举行至 2027年，缅因州巴尔港的MDI生物实验室园区。拟议的课程提供肾研究员 通过亲身实践的研究教育动态平衡的基本概念，并将它们暴露在经典 为肾脏生理学和肾脏学奠定基础的实验。 提出了八个课程模块：肾小球滤过与肾脏疾病遗传学、近端小管功能、 升肢粗大，盐分分泌与平衡，集合管钠转运/ENaC，水分动态平衡， 肾结石和酸碱动态平衡。八个模块中的每个模块都在三个连续两天的时间内运行 轮换(星期一至星期二、星期三至星期四和星期五至星期六)，每次轮换的第一天 涉及密集的实验工作，第二天涉及分析和向 整个课程组。每个参与者将在三轮轮换中完成八个计划单元中的三个。 基于案例研究的负责任行为研究方案将包括在所有人的日程表中 参与者。 肾脏生理学的起源在国家肾脏短期课程中是独一无二的。该课程提供 参与者拥有研究工具，使他们对生理动态平衡的概念有更深的理解 这在正常的临床训练计划中是很难达到的。这门课程对肾脏研究员开放，而且由于 2010年，在空间可用的基础上，住院医生进入肾病。研究员和居民都受益 来自与领导课程模块的肾脏生理学高级研究人员的密切互动。居民，在 特别是与来自不同项目的研究员合作，分享他们对肾脏研究的见解，从而受益 和肾脏病。 MDI生物实验室网站和《J.Am》杂志最近的一篇社论介绍了这一课程。SoC。的 肾脏病(Zeidel等人，JASN 19：649-50,2008)。申请的资金将包括课程学费和参与者 旅费；教职员工生活费、津贴和旅费；设施使用费；咨询服务费；人事费用 需要管理研究教育计划。

Project Summary / Abstract MDI Biological Laboratory seeks NIDDK R25 support for the fourteenth through eighteenth annual offerings of a one-week course for renal fellows, Origins of Renal Physiology. The course will be held August 2023 through 2027 on the MDI Biological Laboratory campus in Bar Harbor, Maine. The proposed course provides renal fellows with hands-on research education in fundamental concepts of homeostasis and exposes them to the classical experiments that form the foundation of renal physiology and nephrology. Eight course modules are proposed: glomerular filtration and genetics of renal disease, proximal tubule function, thick ascending limb, salt secretion and balance, collecting duct sodium transport/ENaC, water homeostasis, renal stone disease, and acid/base homeostasis. Each of the eight modules runs in three consecutive two-day rotations (Monday-Tuesday, Wednesday-Thursday, and Friday-Saturday), with the first day of each rotation involving intensive experimental work, and the second day involving analysis and presentation of the work to the entire course group. Each participant will complete three of the eight planned modules during the three rotations. A case study-based Responsible Conduct in Research program will be included in the schedule for all participants. Origins of Renal Physiology is entirely unique among national renal short courses. The course provides participants with research tools that give them a deeper understanding of concepts of physiological homeostasis which is difficult to attain during normal clinical training schedules. The course is open to renal fellows and, since 2010, on a space-available basis, medical residents entering nephrology. Fellows and residents alike benefit from close interactions with senior investigators in renal physiology who lead the course modules. Residents, in particular, benefit by working with fellows from different programs and sharing their insights into renal research and nephrology. The course is described on the MDI Biological Laboratory website, and in a recent editorial in J. Am. Soc. of Nephrology (Zeidel et al., JASN 19: 649-50, 2008). Requested funds will cover course tuition and participant travel; faculty subsistence, stipends, and travel; facility user fees; consultant services; and personnel costs required to administer the research education program.