TRAINING IN DEVELOPMENTAL BIOLOGY OF MEMBRANE TRANSPORT

描述（改编自申请人的描述）：本申请的目的 计划是培养儿科医学博士M.D.博士医生科学家 在发展领域作为独立调查员的成功职业生涯 生理学和细胞生物学，特别是因为它涉及到理解 个体发育和膜运输的调节。 三大研究重点 1）确定和描述运输 蛋白质及其与细胞生长相关的功能相互作用， 分化和维持稳态; 2）确定 遗传和获得性疾病的发育和遗传基础 膜转运;和3）开发新的治疗策略（例如，基因 治疗）用于膜转运障碍。 包括临床 和基础科学学院的导师与研究兴趣和专业知识， 这些相关领域将提供基本的研究培训经验。 所有 本培训计划的候选人将被要求投入至少 三年来，研究训练。

DESCRIPTION (Adapted from applicant's description): The objective of this proposal is to train pediatric M.D. and M.D./Ph.D. physician-scientists for successful careers as independent investigators in the field of developmental physiology and cell biology, specifically as it relates to understanding the ontogeny and regulation of membrane transport. Three priorities for research training have been identified: 1) To identify and characterize transport proteins and their functional interactions as they relate to cell growth, differentiation and the maintenance of homeostasis; 2) To determine the developmental and genetic bases for inherited and acquired disorders of membrane transport; and 3) To develop new therapeutic strategies (e.g., gene therapy) for disorders of membrane transport. The inclusion of both clinical and basic science faculty preceptors with research interests and expertise in these related fields will provide a basic research training experience. All candidates for this training program will be expected to devote a minimum of three years to research training.