Mechanisms underlying the effects of TNFalpha in bone and haemopoiesis

最近的研究发现，骨骼在血细胞生成中起着重要作用。我们发现，TNF α水平升高（随着年龄的增长而增加，对健康有负面影响）会导致血细胞紊乱，进而发展为白血病。在这个小鼠模型中，血液干细胞和骨骼的数量也减少了。在这些研究中，我们将确定TNFalpha如何导致血液和骨骼缺陷，这可能会导致更好的治疗这类疾病。

Recent studies have identified that bone plays an important role in blood cell production. We have discovered that elevated levels of TNF alpha (which increases with ageing and can negatively impact on health) contributes to a blood cell disorder that can progress to leukaemia. There are also reduced numbers of blood stem cells and bone in this mouse model. In these studies we will determine how TNFalpha contributes to blood and bone defects, which may lead to better treatment of such diseases.