Vaginal Microbicide Acceptability STD/HIV Prevention

描述（由申请人提供）：这是一份修改后的申请。本研究的主要目的是探讨与阴道杀菌剂可接受性相关的因素。样本将从青春期中后期的高危女性中抽取。研究分为两个阶段。第一阶段将包括焦点小组、个人访谈和性别二元访谈，以确定相关的兴趣维度，并发展对文化影响和适当语言的理解。第二阶段将包括对阴道杀菌剂用于性病预防的可接受性的各个方面（在第一阶段开发）的相对重要性的评估。从市场研究的角度出发，选择概念试验作为评估试验使用特定杀微生物剂的可能性的最佳方法。可接受性被操作化为尝试具有特定特性的假设杀菌剂的意图。理论框架改编自计划行为理论。将从创新扩散理论中提取额外的结构。行为意向将通过一系列视频片段进行评估，以模拟现实生活中的性决策场景。修订后的申请包括对建议方法的技术可行性进行试点论证。分析将集中于与可接受性有关的产品特性、与接受性有关的态度和社会规范以及根据初步可接受性估计预测实际使用情况。一个来自青少年医学、心理学和市场营销的多学科团队被召集起来进行研究。该小组在针对青少年开展临床和营销研究方面经验丰富，涉及性行为、性传播疾病和接受性传播疾病相关疫苗等主题。

DESCRIPTION (provided by applicant): This is a revised application. The primary goal of the proposed research is to explore factors associated with vaginal microbicides acceptability. The sample will be drawn from high-risk women in middle and late adolescence. The research is organized into two phases. Phase 1 will consist of focus groups, individual interviews and sexual dyad interviews in order to identify relevant dimensions of interest as well as develop understanding of cultural influences and appropriate language. Phase 2 will consist of an assessment of the relative importance of the various dimensions (developed in Phase 1) on acceptability of vaginal microbicide use for STD prevention. Drawing from the perspective of marketing research, a concept test is chosen as the best methodology to assess the likelihood of a trial of use of a given microbicide. Acceptability is operationalized as intention to try a hypothetical microbicide with specified characteristics. The theoretical framework is adapted from the Theory of Planned Behavior. Additional constructs will be drawn from Diffusion of Innovation Theory. Behavioral intention will be assessed using a series of video vignettes in order to simulate real-life scenarios of sexual decision-making. The revised application includes pilot demonstration of technical feasibility of the proposed approach. Analyses will focus on product characteristics associated with acceptability, attitudes and social norms associated with acceptance and forecasting of actual use based on initial acceptability estimates. A multi-disciplinary team drawn from adolescent medicine, psychology and marketing is assembled to conduct the research. This team is substantially experienced in conducting clinical and marketing research with adolescents addressing topics of sexual behavior, sexually transmitted diseases and acceptance of STD-related vaccines.