Howard University Clinical Research Network for Health Equity

研究摘要 非洲裔美国人在慢性病发病率和死亡率方面存在显著差异。值得注意的是， 消除健康差距需要显著改善慢性病管理，这是 有赖于循证预防性护理的提供和利用。提供高质量的 对非裔美国人的预防性服务受到几个方面的阻碍，包括证据不足 是少数族裔人群在临床研究试验中代表性不足的结果。事实上，美国 预防服务工作组(USPSTF)的建议声明经常引用对 少数民族在临床试验中被视为研究的空白和局限。这影响了临床实践的发展。 满足少数群体需要的指南，当特定疾病的流行病学是 在少数民族人群中有所不同。不仅少数族裔作为研究参与者的代表性不足，而且 作为临床研究人员，非洲裔美国人的代表性也同样严重不足，这在一定程度上是由于 非洲裔美国人在临床研究劳动力中的代表性不足。解决这些差距 需要复杂的系统分析、创新方法的开发、科学证据的产生、 和有效的知识传播。150多年来，霍华德大学为 通过本科和研究生医学教育培养非裔美国医生队伍。此外, 霍华德大学通过积极的研究活动和综合患者来促进少数族裔的健康 关爱哥伦比亚特区及其他地区的居民。电子病历的采用 霍华德大学医院和霍华德大学教师实践计划的系统导致了这一代 关于这些市中心城市低收入非裔美国人的大量临床数据。 为了应对挑战，我们建议成立霍华德大学临床研究 网络(HUCRN)作为RCMI临床研究网络促进健康公平联盟的成员 (RCMI-CRNHE)。这一努力将带来一个创新、高效和有影响力的研究网络 调查对少数民族健康和健康差距具有高度重要性的研究。这件事的意义 该项目源于研究受健康差距影响的人群、慢性病负担、 普遍的健康差距，参与人数不足的临床研究人员。更进一步，我们打算 介绍一种名为mHealth的创新数据科学的新应用。我们将开发一种移动健康 信息技术基础设施、临床研究信息学基础设施，包括临床数据 存储库，我们将进行2项试点研究，以评估基础设施、政策和 已实施的流程。

Research Abstract African Americans experience significant disparities in chronic disease morbidity and mortality. Of note, eliminating health disparities requires significant improvement in chronic disease management, which is dependent on the provision and utilization of evidence-based preventive care. The provision of high-quality preventive services to the African Americans is hindered by several things including insufficient evidence which is a consequence of underrepresentation of minority populations in clinical research trials. In fact, United States Preventive Services Task Force (USPSTF) recommendation statements often cite underrepresentation of minorities in clinical trials as a research gap and limitation. This affects the development of clinical practice guidelines that meet the needs of minority populations when the epidemiology of a particular disease is different in minority populations. Not only is there an underrepresentation of minorities as study participants but there is equally severe underrepresentation of African Americans as clinical investigators, which is due in part to underrepresentation of African Americans in the clinical research workforce. Addressing these disparities requires complex systems analysis, development of innovative approaches, generation of scientific evidence, and effective knowledge dissemination. For over 150 years, Howard University has contributed significantly to the African American physician workforce through undergraduate and graduate medical education. In addition, Howard University has advanced minority health through robust research activities and comprehensive patient care to the residents of the District of Columbia and beyond. The adoption of Electronic Medical Record Systems by Howard University Hospital and Howard University Faculty Practice Plan has led to the generation of vast amounts of clinical data about this inner-city urban low-income African American population. To address the challenges, we propose the formation of the Howard University Clinical Research Network (HUCRN) as an addition to the consortium of the RCMI Clinical Research Network for Health Equity (RCMI-CRNHE). This effort will lead to an innovative, productive, and impactful research network for investigation of studies of high importance in minority health and health disparities. The significance of this project is derived from the necessity to study a health disparity affected population, burden of chronic disease, prevalent health disparities, engagement of an underrepresented clinical research workforce. Further we intend to introduce a new application of innovative data science called mHealth. We will develop a mHealth information technology infrastructure, clinical research informatics infrastructure including a clinical data repository, and we will conduct 2 pilot studies to assess the effectiveness of the infrastructure, policies, and processes that have been implemented.