Asian American Community Cohort of the New York Metropolitan Area

摘要 亚裔美国人（阿萨）是美国增长最快的种族/族裔群体，预计将翻一番，达到4300万 然而，我们对导致阿萨疾病或健康的因素的理解是有限的， 阿萨总体和特定的阿萨亚群在医学研究中的代表性严重不足。到 为了解决关键的人群健康研究空白，NIH呼吁在阿萨病患者中建立一个新的流行病学队列 夏威夷/太平洋岛民（NHPI）我们建议在这一全国性的倡议中作为一个 纽约都会区的阿萨临床/社区现场中心。 全国亚裔美国人社区队列（这里称为AACC）的首要理由是 从“人口组学”的角度，研究生物，生活方式，行为/环境和社会文化 影响阿萨健康的因素，最终目标是降低发病率和死亡率。在纽约地区， AACC-NY将招收韩裔美国成年人--研究最少的阿萨群体--和华裔美国人 成人是最大的阿萨群体。AACC-NY的一个突出特点是我们有能力针对经常被边缘化的、低收入的、 收入，纽约地区的非英语社区，他们最经常经历社会和健康 在流行病学研究中，这些人往往代表性不足。纽约大都会区是 拥有美国任何城市地区中最大和最多样化的阿萨人口，包括320万 居民，其中约40%是韩国人或华裔美国人。从长远来看，CVD和其他代谢 II型糖尿病等疾病将是我们的优先事项;然而，该队列还支持与广泛的 卫生成果，特别是通过在国家群组总体框架内开展合作。 在此资助期间，利用我们非常强大的社区外展，参与和社区 基于与阿萨社区的参与性研究计划，在目标1中，我们将招募3200名阿萨（年龄 25-64岁，包括1600名韩国人和1600名中国人），并进行参与者随访和监测 活动，包括确定具有临床意义的事件。在目标2中，我们将完成基线检查， 包括问卷调查、体格检查、亚临床CVD测量和生物标本采集。在Aim中 3.我们将完成与其他临床/社区领域和协调部门的数据协调和共享 中心.目标4将侧重于短期研究，以审查社会文化、饮食/锻炼， 环境和生物学（遗传学，微生物组）因素与心脏代谢的亚临床标志物相关 疾病的总体和朝鲜和中国种族亚组。 AACC是一个独特的城市平台，有综合社区参与，以解决优先知识差距 关于心血管健康及其在特定阿萨亚群中的差异。这项研究将提供 在阿萨社区，包括经常被边缘化的人， 服务不足。

ABSTRACT Asian Americans (AsA) are the fastest growing racial/ethnic group in the US, projected to double to 43 million people by 2050; however, our understanding of the factors that lead to disease or health in AsA is limited because AsA overall and specific AsA subpopulations have been severely under-represented in medical research. To address key population health research gaps, the NIH has called for a new epidemiologic cohort among AsA and Native Hawaiian/Pacific Islanders (NHPI). We propose to serve in this nation-wide initiative as a Clinical/Community Field Center for AsA in the New York Metropolitan Area. The overarching rationale for a national Asian American Community Cohort (here named the AACC) is to examine from a “populomics” perspective, the biological, lifestyle, behavioral/environmental and sociocultural factors that impact the health of AsA, with the ultimate goal of reducing morbidity and mortality. In the NY area, the AACC-NY will enroll Korean American adults—the most understudied AsA group—and Chinese American adults—the largest AsA group. A strong feature of AACC-NY is our capacity to target often-marginalized, low- income, non-English speaking communities in the NY area, who most often experience social and health disparities and who are often under-represented in epidemiologic research. The New York Metropolitan Area is home to the largest and most diverse AsA population of any urban region in the US, comprising 3.2 million residents, of which ~40% are Korean or Chinese American. In the longer term, CVD and other metabolic diseases such as type II diabetes will be our priority; however, the cohort also supports aims related to broad health outcomes, particularly through collaborations within the overall national cohort framework. In this funding period, leveraging our exceptionally strong community outreach, engagement, and community based participatory research programs with AsA communities, in Aim 1 we will enroll a cohort of 3200 AsA (age 25–64 years, including 1600 Korean and 1600 Chinese) and conduct participant follow up and surveillance activities, including ascertainment of events of clinical significance. In Aim 2 we will complete baseline exam, including questionnaire survey, physical exam, subclinical measure of CVD, and biospecimen collection. In Aim 3, we will complete data harmonization and sharing with Other Clinical/Community Field and Coordinating Centers. Aim 4 will focus on short-term research studies to examine the effect of sociocultural, diet/exercise, environment, and biological (genetics, microbiome) factors in relation to subclinical markers for cardiometabolic disease in overall and Korean and Chinese ethnic subgroups. The AACC is a unique urban platform with integrated community participation to address priority knowledge gaps regarding cardiovascular health and its disparities in specific AsA subpopulations. This research will provide the scientific basis for addressing these challenges in AsA communities, including the often marginalized and underserved.