课题基金 / 基金详情

Clinical And Therapeutic Studies Of Human Filariasis

Clinical And Therapeutic Studies Of Human Filariasis
人类丝虫病的临床和治疗研究
批准号：
6808178
负责人：
THOMAS B NUTMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6808178
关键词：
Filarioidae adolescence (12-20) anthelmintics biopsy blood /lymphatic pharmacology chemokine clinical research clinical trials cytokine drug adverse effect enzyme linked immunosorbent assay eosinophil epidemiology filariasis human subject human therapy evaluation immunocytochemistry onchocerciasis parasitic disease chemotherapy parasitic disease diagnosis pathologic process polymerase chain reaction strongyloidiasis

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相关文献

中文摘要
翻译
由于与治疗盘尾丝虫病、血吸虫病和淋巴丝虫病相关的不良反应可能是严重的、全身性的和衰弱的，因此已经确定并量化了这种治疗后反应的介体。在急性期(最初48小时)，血液中出现细胞内的沃尔巴克氏菌内共生菌，这与治疗后不良反应的炎症介质的存在有关。后来，嗜酸性粒细胞发挥了主要作用，与嗜酸性粒细胞运输相关的趋化因子也是如此。
英文摘要
Because the adverse reactions associated with treatment of onchocerciasis, loiasis, and lymphatic filariasis can be severe, systemic, and debilitating the mediators of this posttreatment reaction have been identified and quantified. In the acute phase (first 48 hours) an intracellular Wolbachia endosymbiont appears in the bloostream and is correlated with the presence of the inflmmatory mediators of the posttreatment adverse reactions. Later, the eosinophil plays a major role as do the chemokines associated with eosinophil trafficking.
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会议论文
CLINICAL AND THERAPEUTIC STUDIES OF HUMAN FILARIASIS
CLINICAL AND THERAPEUTIC STUDIES OF HUMAN FILARIASIS
MOLECULAR DEFINITION OF FILARIAL AND RELATED NONFILARIAL GENES AND PROTEINS
IMMEDIATE HYPERSENSITIVITY RESPONSES--CONTROL IN PARASITIC HELMINTH INFECTIONS