University of Louisville Cagewash Modernization

摘要 路易斯维尔大学（UofL）是一所新兴的卓越机构（IEE），也是23所 美国国立卫生研究院（NIH）指定的国家作为机构发展 奖励（IDEA）状态，服务于医疗服务不足的社区的研究需求。一部分 在IDEA国家计划中，UofL是四个NIH资助的生物医学中心的接收者。 卓越研究（COBRE）项目针对肯塔基州的地方和区域健康危机 和阿巴拉契亚。这些中心包括1）心脏代谢科学中心，2） 微生物学和炎症，3）肝生物学和毒理学，4）癌症免疫学 和免疫疗法。UofL也是美国国立卫生研究院资助酒精中心和 环境研究所超级基金研究中心研究香烟烟雾的影响， 香烟和其他吸入的毒素对心血管系统的影响。UofL请求 306，360.00美元用于位于市中心的A- 塔研究大楼洗笼设施。A塔毗邻六座研究大楼 组成健康科学校园（HSC）的核心，并作为主要的 笼清洗设施的所有啮齿动物物种的HSC和本科贝尔纳普校园。它 也为大型动物笼清洗提供了必要的支持。目前的隧道洗衣机是 超过20年的历史，不符合人体工程学或生态友好。日常维护和维修是 频繁且昂贵。T236型更好的隧道清洗机代表了一项重大的创新， 升级环保、一体化、使用微电脑的洗笼设备 技术.新的隧道清洗机将增加我们目前的笼清洗吞吐量， 25%用于啮齿动物笼和大型动物笼配件，以适应我们不断增长的 啮齿动物和大型动物种群。新的保持架垫圈将为 四个NIH资助的COBRE赠款，环境研究所超级基金，和64名研究人员在24 HSC和Belknap校区的各个部门。一个广泛的，多样化的调查人员和 他们在生物医学和基础科学方面的研究工作将受益于这种设备， 这个共用设施这与NIH-NIGMS的主要任务一致。UofL回波 这些任务，建立了多样性，公平和包容性战略计划， 2017年和HSC多样性和包容性办公室，致力于扩大资金 少数民族就业。

ABSTRACT The University of Louisville (UofL) is an Institution of Emerging Excellence (IEE) and one of 23 states designated by the National Institutes of Health (NIH) as an Institutional Development Award (IDeA) state, serving the research needs of medically underserved communities. As part of the IDeA state program, UofL is the recipient of four NIH funded Centers of Biomedical Research Excellence (COBRE) projects to target local and regional health crises in Kentucky and Appalachia. These include centers in 1) Center for Cardiometabolic Science, 2) Microbiomics and Inflammation, 3) Hepatobiology and Toxicology, and 4) Cancer Immunology and Immunotherapy. UofL is also the recipient of NIH funding for the Alcohol Center and the Envirome Institute Superfund Research Center, which studies the effects of cigarette smoke, e- cigarettes and other inhaled toxins on the cardiovascular system. UofL is requesting $306,360.00 for a modern, innovative, eco-friendly tunnel washer in the centrally located A- Tower Research Building Cagewash Facility. The A-Tower is adjacent to six research buildings that comprise the nucleus of the Health Sciences Campus (HSC), and serves as the primary cage wash facility for all rodent species on the HSC and the undergraduate Belknap campus. It also provides essential support for large animal cage washing. The current tunnel washer is over 20 years old, and is not ergonomically or eco-friendly. Routine maintenance and repair are frequent and costly. The Better Built Tunnel Washer, Model T236, represents a major innovative upgrade in cage wash equipment that is eco-friendly, integrative, and utilizes microcomputer technology. The new tunnel washer will increase our current cage wash throughput capacity by 25% for rodent caging and large animal caging accessories, to accommodate our growing rodent and large animal populations. The new cage washer will provide essential support for the four NIH funded COBRE grants, the Envirome Institute Superfund, and 64 investigators in 24 departments across the HSC and Belknap campus. A broad, diverse range of investigators and their research efforts in both biomedical and basic sciences will benefit from this equipment in this shared-use facility. This aligns with the principal missions of the NIH-NIGMS. UofL echoes these missions, with the establishment of the Diversity, Equity and Inclusion Strategic Plan in 2017 and the HSC Office of Diversity and Inclusion, which is committed to expanding funding and employment of ethnic minorities.