Northeast Biodefense Center

美国东北部非常容易受到新出现的传染病和恐怖主义的影响。与 西尼罗河病毒的爆发，世贸中心的悲剧，以及随后的炭疽袭击，第二区已经 调动丰富的生物医学研究资源推进国家可持续发展的经验和决心 生物防御议程。第二区域机构将建立一个区域卓越中心(RCE)，用于 生物防御和新发传染病研究。这个联合体，东北生物防御中心 (NBC)，将由纽约25个以上学术和研究机构的研究人员组成 泽西州、康涅狄格州、马萨诸塞州和波多黎各。NBC将与州、联邦和 地方政府机构和实验室，以及生物技术和制药公司。专业基础知识 将在六个主题领域开展翻译研究方案：1)与B细胞相关的预防和 治疗；2)细菌致病和治疗；3)疫苗平台；4)病毒致病和治疗 治疗学；5)天花疫苗：临床、免疫和病毒结果；6)病原体检测和 诊断。这些程序将与在信息学、蛋白质组学、 蛋白质表达，单抗，动物模型，以及给药。每项研究 该计划将整合和加强几个有成就的调查人员的工作，并将重点放在选择 病原体和毒素包括炭疽芽孢杆菌、鼠疫耶尔森氏菌、图拉氏方济氏菌、马利伯克霍尔德氏菌、 葡萄球菌肠毒素B、痘病毒和引起出血热或脑炎的病毒。 由于在该地区的重要性、NBC成员的专业知识以及 访问独特的资源，如梅子岛动物疾病中心和调查人员网络和 比较医学方面的临床医生。将建立简化的技术转让程序，以 促进向行业提供疫苗、治疗和诊断。NBC的翻译部门已经 从天花疫苗接种研究开始，并将发展该区域的人类疫苗基础设施 审判。将建立培训计划，通过支持新的 调查人员、高级调查人员和支持人员。已经制定了一项应急计划 为迅速调整NBC的活动并提供包括核心和科学支持在内的设施而开发， 在发生生物防御紧急情况时提供给第一线响应人员。

The northeastern United States is highly vulnerable to emerging infectious diseases and terrorism. With the outbreak of West Nile virus, the World Trade Center tragedy, and subsequent anthrax attacks, Region II has the experience and resolve to mobilize its rich resources in biomedical research to advance the nation's biodefense agenda. Region II institutions will establish a Regional Center of Excellence (RCE) for Biodefense and Emerging Infectious Disease Research. This consortium, the Northeast Biodefense Center (NBC), will comprise investigators at more than 25 academic and research institutions in New York, New Jersey, Connecticut, Massachusetts and Puerto Rico. The NBC will have strong links to state, federal and local government agencies and laboratories, as well as biotech and pharmaceutical companies. Major basic and translational research programs will be pursued in six thematic areas: 1) B-Cell Related Prophylaxis and Therapeutics; 2) Bacterial Pathogenesis and Therapeutics; 3) Vaccine Platforms; 4) Viral Pathogenesis and Therapeutics; 5) Smallpox Vaccine: Clinical, Immune, and Viral Outcomes; 6) Pathogen Detection and Diagnostics. These programs wil_ intersect with cores that provide support in Informatics, Proteomics, Protein Expression, Monoclonal Antibodies, Animal Models, as well as Administration. Each research program will integrate and intensify the work of several accomplished investigators and will focus on select agents and toxins including A. Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia mallei, Staphylococcus enterotoxin B, pox viruses, and viruses that cause hemorrhagic fever or encephalitis. Zoonotic diseases will be emphasized due to significance in this region, expertise of NBC members, and access to unique resources such as Plum Island Animal Disease Center and networks of investigators and clinicians in comparative medicine. Streamlined technology transfer procedures will be established to facilitate delivery to industry of vaccines, therapeutics, and diagnostics. The translational arm of the NBC has begun with a study of smallpox vaccination and will develop the region's infrastructure for human vaccine trials. Training programs will be established to promote biodefense research objectives by supporting new investigators, senior investigators, and support personnel. An emergency response plan has been developed to rapidly realign the NBC's activities and provide facilities, including cores and scientific support, to first line responders in the event of a biodefense emergency.