Non-Invasive Image-Guided HIFU for Breast Cancer Therapy

描述（由申请人提供）：MRI的改进现在已经使得开发和实施范式转换、在线模型预测控制系统以使热疗法治疗更准确和临床实用成为可能。我们的目标是开发和使用这样的控制器在一个新的，完全非侵入性的，MRI引导，相控阵HIFU加热系统，专为乳腺肿瘤的热治疗。这是一个重要的临床研究中心，有大量的患者，目前的治疗可以显着改善。所提出的系统具有几个独特的创新，包括：一个新的，乳房特定的，HIFU相控阵加热系统与集成的MRI接收器线圈;一个最佳的，自适应的，模型预测控制系统;先进的MR温度测量技术;患者特定的治疗计划的基础上创新的MR组织性质和灌注测量;和交互式3D显示临床医生治疗监测和监督控制。这些创新将通过犹他州大学（UU）跨学科科学家、工程师和临床医生、西门子医疗解决方案（SMS）和图像引导治疗（IGT）之间密切的学术/工业合作伙伴关系来实现。这种新型的集成系统及其创新性改进不仅将显着推进乳腺肿瘤热疗法的最新技术水平，而且适用于所有临床部位。 公共卫生相关性：这项研究将开发和测试一种改进的，完全非侵入性的系统，用于高温下的乳腺癌热治疗。该系统将由一个专门设计的超声相控阵设计的加热器组成，该加热器与MRI成像系统耦合。它们将一起加热肿瘤并非侵入性地测量其温度，加热系统和成像系统都由一种新型的模型预测控制系统指导，该系统将在提供有效实用的治疗的同时保持患者的安全。

DESCRIPTION (provided by applicant): Improvements in MRI have now made it possible to develop and implement paradigm-shifting, on-line model- predictive control systems to make thermal therapy treatments more accurate and clinically practical. Our goal is to develop and use such a controller in a novel, completely non-invasive, MRI-guided, phased array HIFU heating system, designed specifically for thermal therapy of breast tumors. This is an important clinical site with a large population of patients for whom current treatments can be significantly improved. The proposed system has several unique innovations including: a new, breast-specific, HIFU phased array heating system with integrated MRI receiver coils; an optimal, adaptive, model-predictive control system; advanced MR temperature measurement techniques; patient-specific treatment planning based on innovative MR tissue- property and perfusion measurements; and interactive 3D displays for clinician treatment monitoring and supervisory control. These innovations will be achieved through the close academic/industrial partnership between interdisciplinary scientists, engineers and clinicians at the University of Utah (UU), Siemens Medical Solutions (SMS) and Image Guided Therapy (IGT). This novel integrated system and its innovative improvements will not only significantly advance the state of the art of thermal therapies for breast tumors, but for all clinical sites. PUBLIC HEALTH RELEVANCE: This study will develop and test an improved, completely non-invasive system for breast cancer thermal therapy at high temperatures. The system will consist of a specially designed ultrasonic, phased array designed heating applicator that is coupled with an MRI imaging system. Together, they will heat the tumor and measure its temperature non-invasively, with both the heating system and the imaging system under guided by a novel, model predictive control system that will keep the patient safe while delivering an effective, practical treatment.