Pathology Core

构成此卵巢癌孢子应用程序的个人研究项目需要 从卵巢癌患者中获取、处理和分析组织病理学材料， 良性卵巢疾病该研究项目需要冷冻和福尔马林固定，石蜡包埋 肿瘤和正常组织的样本。病理学核心增强了已经建立的 M.D.安德森癌症中心妇科肿瘤库和P30赞助的医学博士。安德森癌症 中心集中式组织储存库，支持数据库和内联网访问。核心提供 组织采集由经验丰富的妇科病理学家，以确保高质量的组织， 参与本SPORE的研究者以及其他SPORE的研究者。 病理学核心的目标是提供冷冻组织、石蜡包埋组织和组织病理学检查。 与包括本SPORE提案的研究项目的具体需求相关的专业知识。到 为了实现这一目标，病理学核心有以下具体目标。目标1是保持一个冻结和 卵巢癌、良性卵巢过程和正常卵巢的石蜡包埋组织库。的 主要组织来源是提交给医学部病理科的手术和活检标本。 安德森癌症中心。此外，与杜克大学合作的一项研究提供了额外的卵巢 组织，特别是早期卵巢癌。目的二是为所有临床病例提供病理学检查 SPORE项目中使用的标本，并在必要时提供组织病理学技术服务。 这些技术服务包括免疫组织化学、原位杂交、特定组织的创建、 微阵列载玻片和组织切片的显微切割。目的3是建立血液/尿液/腹水 来自接受卵巢癌和良性卵巢过程手术的患者的储存库。这些流体 为系统检测推定的预后和诊断标志物提供资源， 基于组织的表达阵列和CGH实验。目标4是创建和维护SPORE数据库 对于在两个M.D.安德森癌症中心和杜克大学。此SPORE数据库 是一个虚拟组织库，由所有SPORE研究者以电子方式共享。

The individual research projects that make up this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffinembedded samples of tumor and normal tissue. The Pathology Core augments the already established M.D. Anderson Cancer Center Gynecological Tumor Bank and the P30-sponsored M.D. Anderson Cancer Center Centralized Tissue Repository with supporting database and intranet access. The Core provides tissue acquisition by experienced gynecological pathologists to assure high-quality tissues for the investigators participating in this SPORE as well as investigators of other SPOREs. The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, and histopathological expertise related to the specific needs for the research projects comprising this SPORE proposal. To achieve this goal, the Pathology Core has the following Specific Aims. Aim 1 is to maintain a frozen and paraffin-embedded tissue repository of ovarian cancer, benign ovarian processes, and normal ovary. The primary tissue source is operative and biopsy specimens submitted to the Department of Pathology at M.D. Anderson Cancer Center. In addition, a subcontract with Duke University provides additional ovarian tissues, particularly early stage ovarian cancers. Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and to provide histopathological technical services as necessary. Such technical services include immunohistochemistry, in situ hybridization, creation of specific tissue microarray slides, and microdissection of tissue sections. Aim 3 is to establish a blood/urine/ascites fluid repository from patients undergoing surgery for ovarian cancer and benign ovarian processes. These fluids provide the resources for the systemic testing of putative prognostic and diagnostic markers derived from tissue-based expression array and CGH experiments. Aim 4 is to create and maintain a SPORE Database for all samples collected at both M.D. Anderson Cancer Center and Duke University. This SPORE Database is a virtual tissue repository that is electronically shared by all SPORE investigators.