Microenvironmentally Induced Acute Lymphoblastic Leukemia Cell Quiescence and Chemotherapy Evasion

尽管几乎所有ALL患者都获得了缓解，但仍有一部分儿童和大多数成人在治疗后复发。复发是由于化疗后存活的少量恶性细胞所致。我们已经确定了一个群体的静止细胞，可以代表这个群体。我们认为这一群体是由其在骨髓中的位置来定义的。该项目将描述该人群的特征，并确定其是否免受化疗的影响。

Although almost all patients with ALL achieve a remission, a proportion of children and the majority of adults relapse following treatment. Relapse occurs as a result of a small number of malignant cells that survive chemotherapy. We have identified a population of quiescent cells that could represent this population. We believe this population is defined by its location in the bone marrow. This project will characterize this population and determine whether it is protected from chemotherapy.