SEROPREVALENCE AND PROSPECTIVE RISK FACTOR ANALYSIS OF CYTOMEGALOVIRUS (CMV)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景： 巨细胞病毒(CMV)是婴儿以及免疫系统薄弱的儿童和成年人患病甚至死亡的重要原因。在美国，每年估计有8000名婴儿因出生时感染巨细胞病毒而致残。 传统上，关于CMV的研究主要集中在育龄妇女作为接种CMV疫苗的主要人群，以防止CMV伤害她们的婴儿。虽然大多数人在他们生命中的某个时候会感染CMV，但这种感染通常发生在儿童早期或青春期。尽管已经有关于年轻和老年女性患上巨细胞病毒的研究，但总的来说，关于青春期男性如何感染巨细胞病毒知之甚少。 假设： 这项研究的目标是确定与感染CMV相关的不同风险因素，以及这种病毒在青春期男性中的普遍程度。 具体目标和程序(摘要)： 研究的目的分为三个不同的阶段。第一阶段是确定巨细胞病毒在青春期男性中有多常见，并确定这些男孩感染巨细胞病毒的危险因素。第二阶段是研究两年内有多少青春期男性感染巨细胞病毒，并确定与感染相关的风险因素。最后，第三阶段是确定在第二阶段感染CMV的青少年男孩的血液、尿液和唾液中有多少病毒。 实验设计(摘要)： 在研究的第一和第二阶段，受试者将通过电脑完成一份问卷，调查可能导致巨细胞病毒的风险因素，包括家庭和环境做法。对于那些14岁或14岁以上的受试者，这将包括有关性行为的问题。在第一、第二和第三阶段，将抽取血液进行巨细胞病毒检测；在第二和第三阶段，将采集尿液进行巨细胞病毒检测；最后，在第三阶段，将采集唾液检测样本中的巨细胞病毒含量。 意义(摘要)： 通过收集有关CMV在青春期男孩中有多常见的数据获得的知识将导致未来关于CMV疫苗的研究。研究与感染巨细胞病毒相关的危险因素以及血液、尿液和唾液中巨细胞病毒的含量，可能有助于告诉个人巨细胞病毒是如何在人与人之间传播的，以及谁感染这种疾病的风险最大。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Cytomegalovirus (CMV) is an important cause of illness, and even sometimes death, in infants, as well as children and adults whose immune systems are weak. Each year in the United States (US), an estimated 8000 infants suffer disabilities if they are born with CMV infection. Traditionally, studies about CMV have focused on women of child-bearing age as the primary population to receive a CMV vaccine to prevent CMV from hurting their babies. While most people are infected with CMV at some point in their lives, this infection typically occurs during either early childhood or during adolescence. Though there have been studies about CMV in both young and older females, in general, less is known about how adolescent males get CMV. Hypothesis: The goals of this study are to identify different risks factors associated with getting CMV and how common the virus is in adolescent males. Specific Aims and Procedures (summary): The aims of the study are broken up into three different phases. Phase I is to determine how common CMV is in adolescent males and to identify risk factors of these boys for getting CMV. Phase II is to study how many adolescent males get CMV over two years and to identify the risk factors associated with getting it. Finally, Phase III is to determine how much virus is in the blood, urine, and saliva of those adolescent boys who were infected with CMV during Phase II. Experimental Design (summary): In Phases I and II of the study, subjects will complete a questionnaire by computer, investigating possible risk factors for CMV, including household and environmental practices. For those subjects who are 14 years of age or older, this will include questions about sexual practices. In Phases I, II, and III, blood will be drawn to test for CMV; in Phases II and III, urine will be collected to test for CMV; finally, in Phase III, saliva will also be collected to test the amount CMV present in the samples. Significance (summary): Knowledge gained by collecting data about how common CMV is in adolescent boys will lead to future studies about CMV vaccines. Studying the risk factors associated with getting CMV and the amount of CMV in blood, urine, and saliva, may help teach individuals about how CMV is passed from person to person and who is at greatest risk for getting the disease.