INTRANASAL OXYTOCIN CHALLENGE IN BORDERLINE PERSONALITY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目前的研究旨在作为一个试点研究，以产生数据，检查催产素管理的影响，在个人与边缘型人格障碍（BPD）。 BPD是一种DSM-IV人格障碍，其特征是冲动，愤怒，情感不稳定和身份混淆的慢性和普遍症状。 我们希望探讨是否有催产素调制的社会和压力相关的障碍BPD的初步证据。 如果初步数据有希望，研究人员计划进行更大规模的研究。 本研究将开始招募20名BPD成人和20名正常对照成人。 签署知情同意书后，受试者将接受由研究精神科医生进行的精神病学评估，该精神科医生将确定初步诊断和资格，这将通过DSM-IV轴I障碍的结构化临床访谈和DSM-IV人格障碍的结构化访谈SIDP-IV来确定。 还将进行一系列访谈，以评估包括过去创伤、关系风格、压力水平、信任、自尊和冲动等在内的措施。 基线评估后，受试者将按计划到达临床研究中心，并接受常规实验室检查。 受试者将以双盲方式随机分配，在首次激发时接受催产素或安慰剂。 第二次激发将安排在第一次激发后1 - 2周内，每例受试者将接受替代条件。 挑战性的任务将包括情绪状态的轮廓，词汇决策任务，囚徒困境游戏任务和特里尔社会压力测试。 将对挑战任务和实验室样本的结果进行分析和比较。 假设： 据推测，催产素将导致增强信任为基础的亲社会认知和行为和减少皮质醇反应的心理社会压力在健康对照组和BPD组。 在催产素刺激下，BPD组在基于信任的亲社会认知和行为方面比健康对照组表现出更大的益处。 相反，我们预测在安慰剂挑战下，BPD组的亲社会认知和行为比健康对照组受损更大。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The current study is intended as a pilot study to generate data that examines the impact of oxytocin administration in individuals with Borderline Personality Disorder (BPD). BPD is a DSM-IV personality disorder characterized by chronic and pervasive symptoms of impulsivity, anger, affective instability and identity confusion. We hope to explore whether there is preliminary evidence of oxytocin modulation of social and stress related disturbances in BPD. If preliminary data are promising, the investigators plan to pursue a larger study. The current study will begin with recruitment of twenty adults with BPD and twenty normal control adults. After signing informed consent, subjects will undergo a psychiatric evaluation by a study psychiatrist who will determine preliminary diagnoses and eligibility, which will be determined by administration of the Structured Clinical Interview for DSM-IV Axis I Disorders and the Structured Interview for DSM-IV Personality Disorders SIDP-IV. A series of interviews will also be conducted to assess measures including past trauma, relationship styles, stress levels, trust, self-esteem and impulsivity among other measures. After the Baseline Evaluation, subjects will be scheduled to arrive at the clinical research center and will receive routine laboratory tests. Subjects will be randomized in a double-blind fashion to receive either oxytocin or placebo on their first challenge. The second challenge will be scheduled within 1 to 2 weeks after the first one, and each subject will receive the alternate condition. Challenge tasks will include the Profile of Mood States, the Lexical Decision Task, The Prisoner's Dilemma Game Task and the Trier Social Stress Test. Results of the challenge tasks and laboratory samples will be analyzed and compared. Hypothesis: It is hypothesized that oxytocin will cause enhanced trust-based prosocial cognitions and behaviors and diminished cortisol reactivity to psychosocial stress in both the healthy controls and the BPD group. It is expected that the BPD group will show greater benefits in trust-based prosocial cognitions and behaviors than the healthy controls under the oxytocin challenge. Conversely, we predict to see greater impairment in prosocial cognitions and behaviors in the BPD group than in the healthy controls under the placebo challenge.