Relating multiple dimensions of stress to CVD risk in Filipino adults collaborati

描述（由申请人提供）：心血管疾病和其他非传染性疾病正在迅速成为全世界发展中国家和转型国家发病率和死亡率的主要原因。需要进行研究，以确定推动这一巨大变化的因素。这项FIRCA申请与NHLBI资助的父母赠款有关，题为“菲律宾妇女及其后代的肥胖发展和心血管疾病风险因素聚集”（HL085144）。父母资助的重点是20年内体重轨迹的决定因素，以及饮食、体育活动和体重增加与血压和心血管疾病风险的生物标志物之间的关系。FIRCA的应用扩展了这一研究，以检查广泛的社会心理、环境和行为因素的作用，这些因素代表了压力的多个维度。这两个项目都使用宿务纵向健康和营养调查（CLHNS）的数据，这是一项正在进行的以社区为基础的队列研究，研究对象是1983-84年出生的菲律宾母亲及其子女。通过这项新的研究，我们建议加强菲律宾宿务圣卡洛斯大学人口研究基金会办公室（OPS）与北卡罗来纳大学教堂分校之间正在进行的研究合作，并在OPS建立更强大的慢性病研究重点和数据分析能力。公共卫生相关性：这项FIRCA申请与NHLBI资助的父母赠款有关，题为“菲律宾妇女及其后代的肥胖发展和心血管疾病风险因素聚类”（HL085144，项目期08/01/06-07/31/10），重点研究20年期间体重轨迹的决定因素，以及饮食、身体活动和体重增加与血压和心血管疾病风险的生物标志物之间的关系。这项FIRCA应用扩展了我们的研究，利用宿务纵向健康和营养调查（CLHNS）的数据，研究了广泛的社会心理、环境和行为因素的作用，这些因素代表了压力的多个维度，这是一项正在进行的基于社区的队列研究，研究对象是1983-84年出生的菲律宾母亲及其后代。通过这项新的研究，我们建议加强菲律宾宿务圣卡洛斯大学人口研究基金会办公室（OPS）与北卡罗来纳大学教堂分校之间正在进行的研究合作，并在OPS建立更强大的慢性病研究重点和数据分析能力。

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) and other non-communicable diseases (NCDs) are rapidly becoming leading causes of morbidity and mortality in developing and transitional countries worldwide. Research is needed to identify the factors driving this dramatic change. This FIRCA application is linked to a parent grant funded by NHLBI, titled "Obesity Development and CVD Risk Factor Clustering in Filipino Women & Offspring" (HL085144). The parent grant focuses on determinants of weight trajectories over a 20 year period, and on how diet, physical activity and weight gain relate to blood pressure and biomarkers of CVD risk. The FIRCA application extends this research to examine the role of a wide range of psychosocial, environmental and behavioral factors that represent multiple dimensions of stress. Both projects use data from the Cebu Longitudinal Health and Nutrition Survey (CLHNS), an ongoing community based cohort study of Filipino mothers and their offspring born in 1983-84. Through this new research, we propose to strengthen the ongoing research collaboration between the Office of Population Studies Foundation (OPS) at the University of San Carlos in Cebu, Philippines and the University of North Carolina at Chapel and to develop a stronger chronic disease research focus and data analysis capacity at OPS. PUBLIC HEALTH RELEVANCE: This FIRCA application is linked to a parent grant funded by NHLBI, titled "Obesity Development and CVD Risk Factor Clustering in Filipino Women & Offspring" (HL085144, project period 08/01/06-07/31/10) that focuses on determinants of weight trajectories over a 20 year period, and on how diet, physical activity and weight gain relate to blood pressure and biomarkers of CVD risk. This FIRCA application extends our research to examine the role of a wide range of psychosocial, environmental and behavioral factors that represent multiple dimensions of stress, using data from the Cebu Longitudinal Health and Nutrition Survey (CLHNS), an ongoing community based cohort study of Filipino mothers and their offspring born in 1983-84. Through this new research, we propose to strengthen the ongoing research collaboration between the Office of Population Studies Foundation (OPS) at the University of San Carlos in Cebu, Philippines and the University of North Carolina at Chapel and to develop a stronger chronic disease research focus and data analysis capacity at OPS.