STRESS RESPONSE AND SMOKING CESSATION IN DEPRESSED YOUTH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 吸烟通常始于青春期，并与显著的社会经济和心理社会负担有关，突出了早期和有效干预的必要性。 尽管有证据表明药物（特别是一些抗抑郁（AD）药物）对成人有效，但这些戒烟治疗尚未在青少年中进行研究，也没有研究哪些青少年人群将从这些治疗中受益最多。 在考虑AD药物在戒烟中的作用机制时，HPA轴可能对研究很重要。 HPA对应激和/或尼古丁给药的反应程度已显示调节尼古丁依赖性的进展。 此外，HPA调节和对某些AD药物的反应之间存在联系。 具体目标： 1)评估安非他酮（一种抗抑郁药，也是一种经证实的戒烟成人吸烟者的药理学治疗）是否有助于减少抑郁青少年的吸烟。 2)研究下丘脑-垂体-肾上腺（HPA）调节是否与该人群中安非他酮戒烟反应相关。 3)研究抑郁青少年吸烟者戒烟与安非他酮治疗后HPA活性变化之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cigarette smoking frequently begins in adolescence and is associated with significant socioeconomic and psychosocial burden, highlighting the need for early and effective intervention. Despite evidence for efficacy of pharmacological agents, particularly some anti-depressant(AD) drugs, in adults, these treatments for smoking cessation have not been studied in youngsters, nor has it been studied which population of youth would benefit most from the treatments. In considering the mechanisms of action of AD drugs in smoking cessation, the HPA axis may be important for investigation. the magnitude of HPA response to stress and/or to nicotine administration has been shown to modulate the progression to nicotine dependence. Also, there is a connection between HPA regulation and response to some AD drugs. Specific Aims: 1) To evaluate whether bupropion, an anti-depressant drug that also is a proven pharmacological treatment for smoking cessation adult smokers, is helpful in reducing smoking in depressed adolescents. 2) To examine whether hypothalamic-pituitary-adrenal (HPA) regulation is associated with smoking cessation in response to bupropion in this population. 3) To examine the association between smoking cessation and HPA activity changes in response to bupropion treatment in depressed adolescent smokers.