TREATMENT PREDICTION IN ADOLESCENT AND ADULT DEPRESSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 虽然有越来越多的证据表明，青少年和成人抑郁症的连续性，在临床表现和自然史的相似之处，成熟的差异也被强调。 具体而言，几项研究报告了与成年人相比，抑郁症青少年的脑电图（EEG）的变化，下丘脑-垂体-肾上腺（HPA）活性和抗抑郁药（AD）反应的变化。 该提案旨在了解这些发育差异的潜在机制，并制定一项策略，用于识别可能从AD治疗中获益的青少年和成人患者，特别是安非他酮治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although there is growing evidence for continuities in adolescent and adult depression, with similarities in clinical presentation and natural history, maturational differences also have been highlighted. Specifically, several studies reported variation in electroencephalographic (EEG) cleep changes, hypothalamic-pituitary-adrenal (HPA) activity and antidepressant (AD) response in depressed adolescents compared with the findings in adults. This proposal aims to understand the mechanism(s) underlying these developmental differences and to develop a strategy for use in identifying those patient, both youngsters and adults, who might benefit from AD treatment in general, and from bupropion treatment in particular.