Ethnic Influences on Stress, Energy Balance and Obesity in Adolescents
种族对青少年压力、能量平衡和肥胖的影响
基本信息
- 批准号:10355414
- 负责人:
- 金额:$ 123.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-02-24 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AbbreviationsAccelerometerAccountingAcuteAdolescenceAdolescentAdolescent obesityAdrenal GlandsAdultAffectAfrican AmericanAnthropometryBehavioralBiologicalBiological MarkersBloodBody CompositionBody mass indexCaucasiansCause of DeathCholesterolChronicClientClinicalConsumptionControlled EnvironmentCoronary heart diseaseDepositionDevelopmentDietDiurnal RhythmDual-Energy X-Ray AbsorptiometryEatingEconomic BurdenEconomicsEnergy MetabolismEnvironmentEtiologyFamilyFastingFatty acid glycerol estersFemaleFemale AdolescentsFoodGlucocorticoidsGuidelinesHairHealthHormonesHourHydrocortisoneHypothalamic structureIndividualIndividual DifferencesInsulin ResistanceIntakeInterventionInterviewIsoprostanesKnowledgeLeptinLifeLinkMaintenanceMeasuresMediatingMedicalMetabolic hormoneMetabolic syndromeMethodologyMethodsMexican AmericansMinorityMorbidity - disease rateNational Health and Nutrition Examination SurveyNot Hispanic or LatinoObesityOverweightPalatePatient Self-ReportPhysical FitnessPhysical activityPhysiologicalPituitary GlandPoliciesPovertyPre-Post TestsPrevalencePreventionProcessProtocols documentationPublic HealthRaceRandomizedReportingResearchRisk FactorsRoleSalivaSalivarySamplingScienceSocioeconomic StatusSolidStandardizationStressStressful EventSystemTestingTextTrier Social Stress TestTriglyceridesVariantVisceral fatVisitWeight maintenance regimenWomanYouthabdominal fatacute stressadiponectinbiobehaviorcardiometabolismcostcritical perioddesigndiet and exerciseeffective therapyenergy balanceevidence baseexperiencegirlsgood diethypothalamic-pituitary-adrenal axisimprovedindexingindividualized medicineinsulin sensitivitymaleminority childrenmortalityobesity preventionobesity treatmentprogramspsychologicpsychosocialpsychosocial stressorsracial differenceracial disparityresponsesaliva samplesexsocialsocial factorssocial inequalitystressorsugar
项目摘要
Obesity is one of the most serious public health problems in the US; its prevalence has tripled in the
last three decades and is associated with a range of short- and long-term medical and psychosocial problems.
Adolescence is a critical period for the development and persistence of obesity, and is associated with changes
in diet, physical activity and fitness, fat distribution and insulin sensitivity. There are racial and sex-specific
disparities in the prevalence and burden of obesity. African-American (AA) females have the highest rates of
obesity, and the clustered risk factors for coronary heart disease and metabolic syndrome are twice that of AA
males. The reasons for racial and sex-specific disparities in the prevalence and burden of obesity are not well
understood. AA experience higher stress levels than Non-Hispanic Whites (NHW) due to economic and social
inequalities, and the effect of stress on energy-dense diet and adiposity is more prominent in females. A better
understanding of the mechanisms that link stress to obesity, particularly during adolescence when high rates of
obesity, increased stressful experiences and stronger behavioral and physiological responses to stress emerge,
will contribute to new clinical guidelines for reducing obesity and associated medical conditions in AA females.
The Physiological stress system affects obesity and mediates its adaptive functions via hypothalamic-
pituitary-adrenal (HPA) axis. Prolonged stress-induced glucocorticoid secretion promotes the consumption of
energy-dense diet (EI) and abdominal fat deposition both directly and indirectly through its effects on metabolic
hormones. Stress also reduces physical activity and alters energy balance. The proposed study will examine
the effects of stress and HPA axis on EI and physical activity-related energy expenditure in 100 AA and 100
NHW adolescent females. The effects on EI will be assessed in two contexts, the natural environment and
under controlled conditions incorporating a standardized psychosocial stressor. Stress will be assessed in the
natural environment as multiple domains (i.e., individual, family and social), and several indices of the HPA
axis will be obtained to represent diurnal variation, its status over 12-15 weeks and reactivity to stress. Obesity-
related parameters will be measured through anthropometry, fat distribution and cardio-metabolic biomarkers.
Associations among stress, HPA activity/function, energy balance and obesity-related parameters will be
compared between and within AA and NHW samples. In combination they will improve our understanding of the
social factors and biobehavioral mechanisms of both racial and individual differences in obesity and facilitate the
development of effective treatments within and across racial groups according to the principles of individualized
medicine. To our knowledge, racial differences in objectively-measured diet intake and energy expenditure in
response to stress, or their underlying physiological mechanisms, have not been assessed in adolescents or
adults. This is an important knowledge gap in our efforts to develop better evidence-based translational obesity
prevention and weight-control interventions as the traditional interventions are not effective with minority youth.
肥胖是美国最严重的公共健康问题之一;它的流行率在美国增加了两倍
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('UMA RAO', 18)}}的其他基金
Effects of Early Life Adversity on Substance Use Problems in Adolescents: Biobehavioral Risk Mechanisms
早期生活逆境对青少年药物使用问题的影响:生物行为风险机制
- 批准号:
10719048 - 财政年份:2023
- 资助金额:
$ 123.24万 - 项目类别:
Racial/Ethnic Influences on Early Vascular Aging and Cardiac Strain: Role of Cumulative Stress, Inflammatory and Metabolic Burden
种族/民族对早期血管老化和心脏劳损的影响:累积压力、炎症和代谢负担的作用
- 批准号:
10503004 - 财政年份:2022
- 资助金额:
$ 123.24万 - 项目类别:
Racial/Ethnic Influences on Early Vascular Aging and Cardiac Strain: Role of Cumulative Stress, Inflammatory and Metabolic Burden
种族/民族对早期血管老化和心脏劳损的影响:累积压力、炎症和代谢负担的作用
- 批准号:
10674059 - 财政年份:2022
- 资助金额:
$ 123.24万 - 项目类别:
Prevention of Adolescent Risky Behaviors: Neural Markers of Intervention Effects
预防青少年危险行为:干预效果的神经标志物
- 批准号:
9914097 - 财政年份:2017
- 资助金额:
$ 123.24万 - 项目类别:
Effects of Childhood Maltreatment on Neurocircuitry in Adolescent Depression
童年虐待对青少年抑郁症神经回路的影响
- 批准号:
10237848 - 财政年份:2017
- 资助金额:
$ 123.24万 - 项目类别:
Prevention of Adolescent Risky Behaviors: Neural Markers of Intervention Effects
预防青少年危险行为:干预效果的神经标志物
- 批准号:
9926022 - 财政年份:2017
- 资助金额:
$ 123.24万 - 项目类别:
Ethnic Influences on Stress, Energy Balance and Obesity in Adolescents
种族对青少年压力、能量平衡和肥胖的影响
- 批准号:
9884557 - 财政年份:2017
- 资助金额:
$ 123.24万 - 项目类别:
Effects of Childhood Maltreatment on Neurocircuitry in Adolescent Depression
童年虐待对青少年抑郁症神经回路的影响
- 批准号:
9766891 - 财政年份:2017
- 资助金额:
$ 123.24万 - 项目类别:
Prevention of Adolescent Risky Behaviors: Neural Markers of Intervention Effects
预防青少年危险行为:干预效果的神经标志物
- 批准号:
10116596 - 财政年份:2017
- 资助金额:
$ 123.24万 - 项目类别:
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