RISK FOR SUBSTANCE ABUSE IN DEPRESSED ADOLESCENTS

抑郁青少年药物滥用的风险

• 批准号: 7606330
• 负责人: UMA RAO
• 金额: $ 0.58万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606330
• 关键词: Adolescent; Adrenal Glands; Alcohol or Other Drugs use; Brain region; Comorbidity; Computer Retrieval of Information on Scientific Projects Database; Depressed mood; Development; Disease; Economic Burden; Funding; Grant; High Prevalence; Hypothalamic structure; Individual; Institution; Intervention; Mediating; Mental Depression; Persons; Pituitary Gland; Pituitary-Adrenal System; Psychosocial Stress; Research; Research Personnel; Resources; Risk; Self Administration; Source; Stress; Substance Use Disorder; Substance abuse problem; Testing; United States National Institutes of Health; Variant; Youth; drug of abuse; hypothalamic-pituitary-adrenal axis; psychosocial; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is a high prevalence of comorbidity between depression and substance use disorder (SUD) in adolescents. Co-occurrence of these disorders is associated with significant added psychosocial and economic burden, thus emphasizing the need to identify factors that increase the risk for comorbid illness. Stress acutely increases the risk for substance use, specifically in those with depression. Stress-substance use interactions in depressed persons might be mediated by HPA axis. However, there is inter-individual variability in the degree of HPA response to stress, as well as its ability to modulate self-administration of drugs of abuse. A better understanding of the variations in HPA response potentially might be helpful in the development and testing of more specific interventions for this highly disabling illness. Specific aims: 1) To examine the association between dysregulation in hypothalamic-pituitary-adrenal (HPA) system and risk for the development of SUD in depressed adolescents. 2) To assess whether psychosocial stress makes a contribution to the prediction of SUD in depressed youth, and to evaluate how the contribution of stress varies in those with and without HPA dysregulation. 3) To relate responsivity of the orbitofrontal cortex and associated brain regions to risk for development of SUD in depressed adolescents.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 青少年抑郁症与物质使用障碍（SUD）的共病率较高。 这些疾病的共同发生与显著增加的心理社会和经济负担有关，因此强调需要确定增加共病风险的因素。 压力会急剧增加药物使用的风险，特别是在那些患有抑郁症的人中。 抑郁症患者的应激-物质使用交互作用可能通过HPA轴介导。 然而，HPA对压力的反应程度以及其调节滥用药物自我给药的能力存在个体间差异。 更好地了解HPA反应的变化可能有助于开发和测试针对这种高度致残性疾病的更具体的干预措施。 具体目标： 1)探讨下丘脑-垂体-肾上腺（HPA）系统调节异常与抑郁青少年SUD发生的关系。 2)评估心理社会压力是否有助于预测抑郁青年的SUD，并评估压力的贡献如何在有和没有HPA失调的人中变化。 3)将眶额皮质和相关脑区的反应性与抑郁青少年发生SUD的风险联系起来。