SYSTEMIC ENDOTHELIAL CONSEQUENCES OF PERIODONTAL DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 牙周病是一种牙周组织的细菌感染，可能导致骨骼和牙齿脱落。严重时，口腔的局部感染可能会刺激因子释放到血液中，从而对全身血管造成损害。为了支持这种可能性，最近的研究表明，牙周病患者有内皮(血管细胞内层)受损的迹象。这一效应可能在一定程度上解释了最近的研究表明，这类患者心脏病发作和中风的几率更高。这项拟议的研究将确定对晚期牙周病进行更密集的治疗(适当时进行深度清洁和牙床手术)是否会改善内皮功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodontal disease is a bacterial infection of the periodontal tissues that may lead to bone and tooth loss. When severe, the local infection in the mouth may stimulate release of factors into the blood that cause damage to blood vessels throughout the body. In support of this possibility, recent studies show that patients with periodontal disease have signs of damage to the endothelium (inner lining of cells in blood vessels). This effect might explain, in part, recent studies showing higher rates of heart attack and stroke in such patients. The proposed study will determine whether more intensive treatment of advanced periodontal disease (deep cleaning and gum surgery where appropriate) improves the function of the endothelium.