INTENSIVE INSULIN THERAPY IN THE HOSPITALIZED CF PATIENT: A PILOT STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们假设，在7天的疗程中，接受胰岛素治疗的住院CF患者的肺功能、体重、蛋白质分解代谢和急性炎症标志物将显示出更大的改善。我们建议对12岁及以上的CF患者进行一项试验性研究，这些患者因急性肺加重而住院，并经历高血糖，接受CSII强化胰岛素治疗7天。这些数据将被用来确定一项更大的、明确的研究所需的样本量，以评估该方案的实用性和患者参与的意愿。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that pulmonary function, weight, protein catabolism and acute markers of inflammation will show greater improvement over the course of 7 days in hospitalized CF patients treated intensively with insulin therapy. We propose a pilot study of CF patients age 12 and older, hospitalized for acute pulmonary exacerbation and experiencing hyperglycemia, to be treated with intensive insulin therapy by CSII for 7 days. These data will be used to determine the sample size needed for a larger, definitive study to assess the practicality of the protocol and patient willingness to participate.