RELATIONSHIP BETWEEN INSULIN RESISTANCE & VASCULAR FUNCTION IN CHINESE AMERICANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 据估计，亚裔美国人的糖尿病患病率在10%-20%之间，远远超过全国平均水平。虽然亚裔美国人比高加索人更瘦，但更多的胰岛素抵抗(IR)，但尚不清楚亚裔美国人的IR是否与更高程度的血管功能障碍有关。这项研究旨在评估与肥胖相关的胰岛素抵抗和内皮功能障碍之间的关系。我们计划测试这一假设，即胰岛素抵抗与华裔美国人的内皮依赖性血管扩张缺陷有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of diabetes in Asian Americans has been estimated to be between 10-20%, far exceeding the national average. While Asian Americans have been shown to be leaner yet more insulin resistant (IR) than Caucasians, it is not known whether IR in Asian Americans is associated with higher degree of vascular dysfunction. This study is designed to assess the relationship between insulin resistance and endothelial dysfunction in relation to adiposity. We plan to test the hypothesis that insulin resistance is associated with defective endothelium-dependent vasodilation in Chinese Americans.