PROGESTERONE SUPPRESSION OF PUBERTAL NOCTURNAL LH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在青春期，促黄体生成激素（LH）脉冲频率和幅度在夜间增加，但在白天再次减慢。数据表明，雌二醇（E2）和孕酮（P）在青春期夜间也会增加。我们假设早晨P和E2的增加有助于抑制第二天的LH脉动。一项早期研究表明，E2给药可抑制青春期LH脉动性夜间增加。然而，成人研究表明，P是LH脉冲频率减慢的主要效应物。尚不清楚P给药是否抑制青春期夜间LH脉动性增加。为了进一步评估这一点，我们将研究正常的早期到中期的女孩。志愿者将在GCRC接受频繁的抽样研究。将在1600 h和2000 h给予口服P或安慰剂（根据随机化）。从1900-0900 h频繁采血将允许评估P或安慰剂给药后LH脉冲频率的过夜变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During puberty, luteinizing hormone (LH) pulse frequency and amplitude increase overnight, but slow again during the day. Data suggest that estradiol (E2) and progesterone (P) also increases overnight during puberty. We have hypothesized that morning increases in P and E2 help suppress LH pulsatility during the following day. An earlier study demonstrated that E2 administration suppresses nocturnal increases in LH pulsatility during puberty. However, studies in adults suggest that P is the principal effector of LH pulse frequency slowing. It is unknown if P administration suppresses nocturnal increases in LH pulsatility during puberty. To assess this further, we will study normal early to midpubertal girls. Volunteers will undergo a frequent sampling study in the GCRC. Oral P or placebo will be administered (according to randomization) at 1600 h and 2000 h. Frequent blood sampling from 1900-0900 h will allow assessment of overnight changes in LH pulse frequency after either P or placebo administration.