ASSESSMENT MEASURES FOR ALZHEIMER'S DISEASE PRIMARY PREVENTION TRIALS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究项目的两个主要目标是测试将在本试验中使用的问卷的有效性，并降低开展预防试验的成本。阿尔茨海默病合作研究(ADCS)是开发临床评估和工具的先驱，目前这些工具用于对患有记忆主诉、轻度认知障碍(MCI)的患者和健康老年人进行临床研究。ADCS开发的新的或改进的措施和问卷将用于650名健康的非痴呆症老年人。研究人员的目标是找出这些问卷是否对发现正常衰老的变化或阿尔茨海默病的早期迹象敏感。这些仪器将在未来的阿尔茨海默病初级预防研究中应用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The two main goals of this research project are to test the effectiveness of the questionnaires to be used in this trial and to reduce the cost of running a prevention trial. The Alzheimer's Disease Cooperative Study (ADCS) has been a pioneer in developing clinical assessments and instruments that are currently used in clinical studies in patients with memory complaints, MCI (Mild Cognitive Impairment) and in healthy elderly. The new or improved measures and questionnaires that have been developed by the ADCS will be used in 650 healthy, non-demented elderly. Investigators aim to find out whether these questionnaires will be sensitive to detect changes in normal aging or early signs of Alzheimer's disease. These instruments in turn will be implemented in future Alzheimer's Disease primary prevention studies.