权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk Factors

慢性创伤性脑病：检测、诊断、病程和危险因素

基本信息

批准号：
10314027
负责人：
JEFFREY L. CUMMINGS
金额：
$ 235.39万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-12-15 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10314027
关键词：
Address Age Alzheimer&apos s Disease Amygdaloid structure Amyloid Astrocytes Attention Award Behavior Behavioral Biological Markers Boxing Brain Brain Chemistry Brain Concussion Brain Diseases Case Study Clinical Cognitive Consensus Consensus Workshop Control Groups Corpus Callosum Country Data Databases Degenerative Disorder Dementia Deposition Detection Diagnosis Diagnostic Diffusion Magnetic Resonance Imaging Disease Epilepsy Exposure to Frequencies Functional Magnetic Resonance Imaging Genetic Genetic Polymorphism Gold Grant Growth Head Image Impairment Individual Intervention Life Liquid substance Literature Longitudinal Studies Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Manufactured football Measures Methods Modeling Moods Motor Multicenter Studies Nerve Degeneration Neurocognitive Neurodegenerative Disorders Neurologic Neurons Pattern Plasma Play Positron-Emission Tomography Prevention Process Proxy Publishing Recording of previous events Reporting Research Personnel Rest Risk Risk Factors Science Septum Pellucidum Signs and Symptoms Sports Subgroup Symptoms Syndrome Tauopathies Testing Thinness Tracer Trauma Traumatic Brain Injury Validation Validity and Reliability Variant Writing Youth brain abnormalities chronic traumatic encephalopathy clinical diagnosis clinical diagnostics college contact sports data portal design diagnostic accuracy diagnostic criteria effective intervention experience follow-up head impact high risk high school in vivo infancy insight men military service multidisciplinary neuroimaging neuropathology novel physical abuse preventive intervention public health relevance service member subconcussion symposium tau Proteins tau-1 tool uptake white matter

项目摘要

DESCRIPTION (provided by applicant): Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by a distinct deposition of an abnormal form of the tau protein in a pattern that is unique from other diseases, including Alzheimer's disease (AD). CTE has been found most often in professional contact sport athletes (e.g., boxing, football) who have been subjected to repetitive blows to the head resulting in concussive and subconcussive trauma. Neuropathologically-confirmed CTE has been reported in individuals as young as 17 and in athletes who only played sports through high school or college. It also has been found in non-athletes who experienced repetitive head impacts, including epileptics, victims of physical abuse, and military service members. In contrast to what may be inferred by the extensive media attention on CTE, the science of CTE remains in its infancy; critical questions remain, such as whether or not it is a common disease. Although the neuropathological features of CTE have become further clarified in recent years, the clinical presentation of CTE is still not well characterized, even though there have been case reports in the literature of "dementia pugilistica" in boxers since the early 1900's. Clinical diagnostic criteria have only recently been published and lack validation. Neuroimaging and fluid biomarkers developed for the diagnosis of other neurodegenerative diseases have only been used in preliminary studies. There is thus an urgent need to develop accurate methods for detecting and diagnosing CTE during life so that effective interventions for prevention and treatment can be developed. Moreover, though a history of repetitive head impacts is a necessary risk factor for CTE, it alone is not sufficient. There is a need to understand what specific aspects of the head impact exposure places an individual at increased risk for CTE and to examine potential genetic modifiers of that risk. To address these needs, we propose a multidisciplinary, multicenter, longitudinal study of former athletes with high exposure to repetitive head impacts (120 former NFL players with and without symptoms) or medium exposure to repetitive head impact (60 former college football players with and without symptoms) and a control group of 60 asymptomatic same-age men without any history of repetitive head impact exposure or traumatic brain injury. The aims of our proposal are: (1) to collect and analyze neuroimaging and fluid biomarkers for the detection of CTE during life, including the use of a novel PET tracer to measure the amount of abnormal brain tau; (2) to characterize the clinical presentation of CTE; (3) to examine the progression of CTE over a three year period; (4) to refine and validate diagnostic criteria for the clinical diagnosisof CTE; (5) to investigate genetic and head impact exposure risk factors for CTE; and (6) to share project data with researchers across the country and abroad in order to expedite growth in our understanding and treatment of this disease.

项目成果

期刊论文数量（29）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Amyloid PET across the cognitive spectrum in former professional and college American football players: findings from the DIAGNOSE CTE Research Project.

DOI：
10.1186/s13195-023-01315-5
发表时间：
2023-10-05
期刊：
Alzheimer's research & therapy
影响因子：
0
作者：
通讯作者：

Exposure to Repetitive Head Impacts Is Associated With Corpus Callosum Microstructure and Plasma Total Tau in Former Professional American Football Players.

DOI：
10.1002/jmri.27774
发表时间：
2021-12
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
0
作者：
Kochsiek J;O'Donnell LJ;Zhang F;Bonke EM;Sollmann N;Tripodis Y;Wiegand TLT;Kaufmann D;Umminger L;Di Biase MA;Kaufmann E;Schultz V;Alosco ML;Martin BM;Lin AP;Coleman MJ;Rathi Y;Pasternak O;Bouix S;Stern RA;Shenton ME;Koerte IK
通讯作者：
Koerte IK

Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy.

DOI：
10.14336/ad.2020.0908
发表时间：
2021-09
期刊：
Aging and disease
影响因子：
7.4
作者：
Muraoka S;DeLeo AM;Yang Z;Tatebe H;Yukawa-Takamatsu K;Ikezu S;Tokuda T;Issadore D;Stern RA;Ikezu T
通讯作者：
Ikezu T

Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease.

DOI：
10.1038/s43587-021-00138-z
发表时间：
2021-12
期刊：
NATURE AGING
影响因子：
0
作者：
Fang, Jiansong;Zhang, Pengyue;Zhou, Yadi;Chiang, Chien-Wei;Tan, Juan;Hou, Yuan;Stauffer, Shaun;Li, Lang;Pieper, Andrew A.;Cummings, Jeffrey;Cheng, Feixiong
通讯作者：
Cheng, Feixiong

Neuropsychological test performance of former American football players.