MULTICENTER ANALYSIS OF HIPPOCAMPAL MORPHOLOGY IN MCI

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该提案将提供30例轻度认知功能障碍（MCI）患者海马萎缩影像学评估的中心间可靠性、灵敏度和特异性[根据纵向随访，已知其中15例为早期AD]，并与30例老年对照组进行比较。四种成像技术将在来自全国多个中心的通用数据集上进行评估。选择这四种技术是基于它们在评价内侧颞叶萎缩中的有效性。这些措施包括：1.马约小组的体积评估技术。2.由纽约大学小组对内侧颞叶萎缩进行定性评估。3. Jobst等人的线性评估技术。4.加州大学洛杉矶分校采用的三维绘图技术。参与本多中心方案的具有MCI和常见MRI采集序列共同定义的中心为：1.加州大学洛杉矶分校ADRC和神经成像实验室2。马约诊所ADRC和放射科3。纽约大学ADRC和放射科的具体目标：（1）使用对照组和MCI患者的共同共享扫描数据库，获得这四种技术的中心间可靠性数据。(2)获得各中心在识别MCI与对照受试者时这四种评估技术的灵敏度和特异性数据;[和MCI组群中的15名早期AD受试者]（3）使用来自本研究的中心范围的规范性对照数据，以及其关于海马体积变异性的数据，提供基于网络的工具，使用具体目标#2中确定的最有效和临床有用的技术评估未来的MCI患者。该基于网络的工具将通过互联网提供给任何诊所或中心，并且将是独立于平台的，以允许基于来自本提案的成像和临床数据的共享资源来评估任何给定受试者的早期AD风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal will provide intercenter reliability, sensitivity, and specificity on imaging assessment of hippocampal atrophy in 30 patients with mild cognitive impairment (MCI) [15 of which are known to have incipient AD based upon longitudinal follow-up] compared to 30 elderly controls. Four imaging techniques will be assessed on a common data set derived from multiple centers across the country. These four techniques have been chosen based upon their demonstrated usefulness in evaluating medial temporal atrophy. These include: 1. The volumetric assessment technique of the Mayo group. 2. The qualitative assessment of medial temporal lobe atrophy performed by the NYU group. 3. The linear assessment technique of Jobst et al. 4. The three-dimensional mapping technique employed at UCLA. The centers participating in this multisite protocol who share common definitions of MCI and common MRI acquisition sequences are: 1. The UCLA ADRC and Laboratory of Neuro Imaging 2. The Mayo Clinic ADRC and Department of Radiology 3. The NYU ADRC and Department of Radiology Specific aims: (1) Obtain inter-center reliability data on these four techniques using a common shared database of scans obtained on both control and MCI patients. (2) Obtain sensitivity and specificity data on these four assessment techniques across centers in the identification of MCI vs. control subjects; [and the 15 incipient AD subjects within the MCI cohort] (3) Using the center-wide normative control data derived from this study, with its data on hippocampal volumetric variability, provide web-based tools to assess future patients with MCI using the most efficient and clinically useful technique identified in specific aim #2. This web-based tool will be made available to any clinic or center via the Internet and will be platform independent to allow assessment of any given subject's risk for incipient AD based up on the shared resources of imaging and clinical data derived from this present proposal.