CORONARY ARTERY DISEASE AND INSULIN RESISTANCE IN MEXICAN AMERICAN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 项目1的目标是对通过冠状动脉疾病(CAD)指标病例确定的墨西哥裔美国人(MA)家庭进行集中表型，以研究胰岛素抵抗(IR)、胰岛素抵抗综合征和动脉粥样硬化之间的生理和遗传相互关系。我们推测，胰岛素抵抗、代谢综合征的成分和CAD有很强的基础，胰岛素抵抗和代谢综合征是MA中CAD的主要贡献因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of project 1 is to intensively phenotype Mexican American (MA) families which have been ascertasined via an index case with coronary artery disease (CAD) in order to investigate physiologic and genetic interrelations between insulin resistance (IR), the insulin resistance syndrome, and athersclerosis. We hypothize that there is a strong basis for IR, components of the metabolic syndrome, and CAD, and that IR and the metabolic syndrome are major contributing factors to CAD in MA.