ENDOTHELIAL DYSFUNCTION IN TERM AND NEAR-TERM NEONATES WITH PULMONARY HYPERTENS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 新生儿持续性肺动脉高压(PPHN)是足月儿和近月儿发病率和死亡率的重要原因。越来越多的证据表明，内皮功能异常可能在PPHN中发挥作用，这主要是来自动物研究。据我们所知，没有专门评估经历过PPHN的新生儿的内皮功能的信息。这项研究的目的是提供使用非侵入性技术的PPHN可能存在的内皮功能障碍的初步信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Persistent pulmonary hypertension of the newborn (PPHN) is an important cause of morbidity and mortality in term and near-term infants. There is accumulating evidence, largely from animal studies, that abnormalities of endothelial function may play a role in PPHN. To our knowledge, there is no information specifically assessing endothelial function in neonates who have experienced PPHN. The purpose of this study is to provide preliminary information about possible endothelial dysfunction in PPHN using a noninvasive technique.