MATRIX METALLAPROTENINASES AS BIOCHEMICAL MARKERS IN VASCULAR DEMENTIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究拟对痴呆患者的脑脊液和脑磁共振波谱进行检查。 具体地，特定酶（例如，MMP-2）将与指示神经轴突损伤和神经胶质增生的神经代谢物（NAA，胆碱）相关。 根据以前的观察，我们假设这些标记物将存在于血管损伤导致或导致痴呆的患者中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The present study proposes to examine CSF and brain magnetic resonance spectroscopy in dementia patients. Specifically, the activity of specific enzymes (e.g., MMP-2) will be correlated with neurometabolites that indicate neuro-axonal injury and gliosis (NAA, Choline). Based on previous observations, we hypothesize that these markers will be present in patients for whom vascular injury contributes to or causes their dementia.