General Clinical Research Center

本提案要求继续支持大卫的综合临床研究中心（GCRC） 加州大学洛杉矶分校格芬医学院。作为一个主要的医学院，加州大学洛杉矶分校需要一个有组织的临床 研究单位，以履行其教学，研究和病人护理的使命。UCLA GGRC将包含 以下组成部分：护理，生物营养，生物统计，生物信息学，RSA，培训，核心 实验室，分子和临床病理学支持核心（新要求），脑成像核心和 CReFF程序。在下一个周期，加州大学洛杉矶分校GCRC将重点推进门诊和住院病人 研究，几乎95%在类别“A”下，这已经超过了我们目前的配置。的新状态 2007年将开放GCRC的住院和门诊部。该计划的方向将继续根据 同样的领导经验。GCRC将继续在下一代的培训中发挥关键作用 临床研究者。事实上，K30计划被整合到UCLA-GCRC和GCRC中， 加州大学洛杉矶分校的附属机构GCRC也是22 T32课程学员的重要资源 博士后奖学金计划，NCRR赞助的K12计划，以及K23和K24 获奖者此外，GCRC在整个UCLA临床研究企业中发挥着关键作用。一 目前的申请共提交了152份协议，它们代表了面向患者的研究 来自医学院不同部门以及护理和公共卫生学院 这些活动得到了GCRC的支持。由此产生的尖端翻译研究将 对国家的卫生保健产生重要影响，例如：艾滋病/艾滋病毒相关 针对成人和儿童患者、不同肿瘤/血液系统疾病、阿尔茨海默病、 少数群体的抑郁症，炎症性肠病和纤维肌痛，糖尿病，动脉粥样硬化， 肥胖症，应用最先进的成像和分析技术来研究不同的大脑疾病 成人和儿童。在加州大学洛杉矶分校-GCRC进行的研究得到了同行评审赠款的支持 总额约为1亿美元，其中95%由NIH资助。GCRC的核心作用体现在 在医院领导和学院院长的大力支持和承诺下， 药

This proposal requests continuing support for the General Clinical Research Center (GCRC) at the David Geffen School of Medicine at UCLA. As a major medical school, UCLA requires an organized clinical research unit to carry out its missions of teaching, research and patient care. The UCLA GGRC will contain the following components: Nursing, Bionutrition, Biostatistics, Bioinformatics, RSA, Training, Core Laboratory, Molecular and Clinical Pathology Support Core (new request), Brain Imaging Core and the CReFF program. For the next cycle, the UCLA GCRC will focus on advancing with outpatient and inpatient studies, almost 95% under catregory "A" which have outpaced our current configuration. A new state of the art inpatient and out patient GCRC units will be open in 2007. The program direction will continue under the same experienced leadership. The GCRC will continue it's critical role in the training of the next generation of clinical investigators. Indeed, the K30 program is integrated within the UCLA-GCRC and the GCRC's from the UCLA affiliate institutions. The GCRC serves also as a essential resource for trainees enrolled in 22 T 32 post-doctoral fellowship programs, the NCRR-sponsored K12 program, as well as for K23 and K24 awardees. Furthermore, the GCRC plays a critical role within the overall UCLA clinical research enterprise. A total of 152 protocols are submitted with the current application and they represent patient-oriented research from different departments in the School of Medicine as well as from the School of Nursing and Public Health and such activities are enhanced by GCRC support. The resulting cutting edge translational studies will have important impact on the health care of the nation, for example among others: AIDS/HIV related protocols for adult and pediatric patients, different oncologic/hematologic disorders, Alzheimer's disease, depression in minority groups, inflamatory bowel disease and fibromyalgia, diabetes, atherosclerosis, obesity, the application of state of the art imaging and analytical techniques to study different brain disorders in adult and children. The research carried out at the UCLA -GCRC is supported by peer-reviewed grants that total approximately $100 million of which 95% are NIH funded. The central role of the GCRC is reflected by the strong support and commitment from the leadership of the hospital and the Dean of the School of Medicine.