THE DMAC STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 脱氧核糖核酸（DNA）甲基化是表观遗传学研究的一个新兴领域，被认为在肿瘤发生中起重要作用。 美国国立卫生研究院（NIH）最近的一项申请（RFA）（AA-06-005），UCHC的一个多学科研究小组（Bonkovsky，Hesselbrock，Lalande和Lambrecht博士）对此做出了回应，将酒精及其代谢的表观遗传效应作为一个重要的研究领域。 长期以来，酒精与癌症有关，最近与DNA甲基化水平增加有关。在这项初步研究中，我们建议确定慢性酗酒者的DNA甲基化模式是否以及如何与合适的对照组不同。这将是发现慢性酒精依赖受试者的DNA甲基化模式是否改变的第一步，并为后来向NIH和其他外部资助机构提出的更大的建议提供重要的试点数据，这些建议专注于酒精及其代谢物影响癌症风险和其他表观遗传效应的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Deoxyribonucleic acid (DNA) methylation, which is thought to play an important role in carcinogenesis, is an emerging area of epigenetic research. A recent Request For Applications (RFA) (AA-06-005) from the National Institutes of Health (NIH), to which a multidisciplinary investigative group from UCHC responded (Drs. Bonkovsky, Hesselbrock, Lalande, and Lambrecht) targeted epigenetic effects of alcohol and its metabolism as an important area of research. Alcohol has long been associated with cancer and has recently been associated with increased DNA methylation levels. In this pilot study, we propose to determine whether and how DNA methylation patterns in chronic alcoholics are different from suitable controls. This will be the first step in finding out if DNA methylation patterns are altered in subjects with chronic alcohol dependence and provide important pilot data for later, larger proposals to the NIH and other external funding agencies focused on mechanisms whereby alcohol and its metabolites influence cancer risk and other epigenetic effects.